Histopathologic characterization of human breast cancer in correlation with estrogen receptor status. A comparison of immunocytochemical and biochemical analysis

A detailed histopathologic analysis of 399 primary breast carcinomas was performed, and several morphologic features were correlated with the estrogen receptor (ER) status. In all cases ER status was determined immunocytochemically by estrogen receptor immunocytochemical assay (ER‐ICA). In 359 carci...

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Bibliographic Details
Published in:Cancer 1988-03, Vol.61 (6), p.1149-1154
Main Authors: Reiner, Angelika, Reiner, Georg, Spona, Jürgen, Schemper, Michael, Holzner, Johann H.
Format: Article
Language:English
Subjects:
Adenocarcinoma - analysis
Adenocarcinoma - pathology
Adenocarcinoma, Mucinous - analysis
Adenocarcinoma, Mucinous - pathology
Biological and medical sciences
Breast Neoplasms - analysis
Breast Neoplasms - pathology
Carcinoma - analysis
Carcinoma - pathology
Carcinoma, Intraductal, Noninfiltrating - analysis
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Papillary - analysis
Carcinoma, Papillary - pathology
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Methods
Neoplasms, Hormone-Dependent - analysis
Neoplasms, Hormone-Dependent - pathology
Receptors, Estrogen - analysis
Tumors
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Summary:A detailed histopathologic analysis of 399 primary breast carcinomas was performed, and several morphologic features were correlated with the estrogen receptor (ER) status. In all cases ER status was determined immunocytochemically by estrogen receptor immunocytochemical assay (ER‐ICA). In 359 carcinomas ER status was also biochemically determined. Invasive lobular, mucoid, and tubular carcinomas rather than ductal carcinomas were ER‐positive more frequently in ER‐ICA. Medullary and papillary carcinomas had corresponding lower or higher ER positivity, respectively, by both methods. The correlation of histologic grade and its single factors with ER status was statistically significant by both methods. Lymphocytic reaction to tumor showed a significant inverse relationship to ER status by both methods. A statistically significant higher number of ER‐positive carcinomas in ER‐ICA and dextran‐coated charcoal assay (DCC) occurred when elastic tissue was present. Different associations were found between stromal content, tumor diameter, and ER status in DCC and ER‐ICA, respectively.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19880315)61:6<1149::AID-CNCR2820610615>3.0.CO;2-Z