A Murine Homologue of the Human Daz Gene Is Autosomal and Expressed only in Male and Female Gonads

We have isolated a homologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is autosomal, located on chromosome 17 and apparently single copy. The predicted protein is highly homologous to that encoded by the DAZ gene in the N-terminal reg...

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Bibliographic Details
Published in:Human molecular genetics 1996-04, Vol.5 (4), p.513-516
Main Authors: Cooke, Howard J., Lee, Muriel, Kerr, Shona, Ruggiu, Matteo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Deleted in Azoospermia 1 Protein
DNA, Complementary
Female
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
Male
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Ovary - metabolism
Protein Biosynthesis
Proteins - genetics
RNA-Binding Proteins - biosynthesis
RNA-Binding Proteins - genetics
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Testis - metabolism
Y Chromosome
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Summary:We have isolated a homologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is autosomal, located on chromosome 17 and apparently single copy. The predicted protein is highly homologous to that encoded by the DAZ gene in the N-terminal regions of the two proteins and this homology is not confined to the RNA binding domain. Analysis of its expression pattern by reverse transcription PCR shows that the transcript is only detectable in male and female gonads and that testes lacking germ cells do not contain detectable amounts of transcript. We have been unable to detect a Y-linked DAZhomologue in mouse and our results point to the possibility of a role for autosomal RNA binding proteins in mammalian gametogenesis.
ISSN:0964-6906
1460-2083
1460-2083
DOI:10.1093/hmg/5.4.513