Histamine release from mast cells and monocytes: the effects of azelastine, reproterol and vitamin A-analogues

• Published in: Inflammation research 1996-03, Vol.45 Suppl 1 (S1), p.S5-S6
• Main Authors: Bolsmann, K, Braam, U, Eichelberg, D, Greven, T, Jungbluth, C, Schmutzler, W, Zwadlo-Klarwasser, G
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Agonists - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antioxidants - pharmacology; beta Carotene; Carotenoids - pharmacology; Dose-Response Relationship, Drug; Drug Combinations; Etretinate - pharmacology; Histamine H1 Antagonists - pharmacology; Histamine Release - drug effects; Humans; Isotretinoin - pharmacology; Keratolytic Agents - pharmacology; Mast Cells - drug effects; Mast Cells - metabolism; Metaproterenol - analogs & derivatives; Metaproterenol - pharmacology; Monocytes - drug effects; Monocytes - metabolism; Phthalazines - pharmacology; Quinolines - pharmacology; Superoxide Dismutase - pharmacology; Theophylline - analogs & derivatives; Theophylline - pharmacology
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/BF03354062

In addition to basophils, monocytes and lymphocytes are important sources of histamine in blood which may be released on stimulation with either A 23187, C5a or substance P. This release may be inhibited significantly by high concentrations of disodium cromoglycate (DSCG) but not by ketotifen. Free radicals have been shown to originate from monocytes and to activate mast cells. This might be an important process in inflammatory reactions. Therefore we tested the effects of some radical scavengers, e.g. superoxide dismutase (SOD), two dihydrochinolines (MG and MDS), beta -carotene and two vitamin A-analogues (isotretinoin and etretinate) on the histamine release induced by Con A from human adenoidal mast cells. beta -Carotene was also tested in C5a-stimulated human peripheral blood monocytes. The H sub(1)-blocker azelastine and the beta sub(2)-agonist reproterol were included in the study for comparison.