Efficacy of Salmonella enteritidis (SE)-immune lymphokines from chickens and turkeys on SE liver invasion in one-day-old chicks and turkey poults

We have shown previously that increased resistance to Salmonella enteritidis (SE) organ infectivity in 1-day-old chicks was conferred by the immunoprophylactic administration of SE-immune lymphokines (SEILK). These lymphokines have been found to be present in the cell culture media of concanavalin A...

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Bibliographic Details
Published in:Avian diseases 1996-01, Vol.40 (1), p.186-192
Main Authors: Ziprin, R.L. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX.), Kogut, M.H, McGruder, E.D, Hargis, B.M, DeLoach, J.R
Format: Article
Language:English
Subjects:
ANIMALES JOVENES
Animals
Chickens
Chicks
CONTROL DE ENFERMEDADES
CONTROLE DE MALADIES
DINDON
FACTEUR IMMUNOLOGIQUE
FACTORES INMUNOLOGICOS
FOIE
HIGADO
JEUNE ANIMAL
Liver
Liver Diseases - microbiology
Liver Diseases - prevention & control
Liver Diseases - veterinary
Lymphokines - administration & dosage
P values
PAVO
PODER PATOGENO
POLLITO
Poultry Diseases - microbiology
Poultry Diseases - prevention & control
Poults
POUSSIN
POUVOIR PATHOGENE
RESISTANCE AUX MALADIES
RESISTENCIA A LA ENFERMEDAD
Salmonella
SALMONELLA ENTERITIDIS
Salmonella infections
Salmonella Infections, Animal - microbiology
Salmonella Infections, Animal - prevention & control
SALMONELLOSE
SALMONELOSIS
T lymphocytes
Treatment Outcome
Turkeys
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Summary:We have shown previously that increased resistance to Salmonella enteritidis (SE) organ infectivity in 1-day-old chicks was conferred by the immunoprophylactic administration of SE-immune lymphokines (SEILK). These lymphokines have been found to be present in the cell culture media of concanavalin A-stimulated splenic lymphocytes obtained from SE-immunized chickens. In the present study we evaluated whether turkeys also produced SEILK and whether these lymphokines could protect 1-day-old chicks and turkey poults against SE liver invasion. In addition, we tested the ability of our original chicken SEILK to reduce SE liver invasion in turkey poults. Day-of-hatch chicks and turkey poults were injected intraperitoneally with immune lymphokines of either chicken or turkey origin. One hour later the birds were challenged per os with SE, and 20 hours later their livers were examined by bacteriological methods for the presence of SE. We found that SEILK induced from the splenic lymphocytes of SE-immunized turkeys reduced SE liver invasion in both chicks and turkey poults. Conversely, we also determined that SEILK produced by chicken splenic lymphocytes conferred protection against invasion by SE in turkey poults. This research is the first report of the production of SEILK in turkeys and also the first report on the cross-species activity of these effector molecules in chickens and turkeys
ISSN:0005-2086
1938-4351
DOI:10.2307/1592388