Activation of an S6 kinase from rat astroglial cells by cAMP

Forskolin and isoproterenol, agonists of adenylate cyclase activity, and dibutyryl cyclic AMP, stimulated an S6 kinase activity in astroglial cells. This activity was insensitive to the thermostable inhibitor of cyclic AMP-dependent protein kinase and had the same behaviour on a DEAE-Sephacel column...

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Bibliographic Details
Published in:FEBS letters 1988-02, Vol.228 (2), p.219-222
Main Authors: Pierre, Michel, Gavaret, Jean-Michel, Matricon, Carole, Pomerance, Martine, Jacquemin, Claude, Toru-Delbauffe, Danièle
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Astrocyte
Astrocytes - enzymology
Biological and medical sciences
Bucladesine - pharmacology
Colforsin - pharmacology
cyclic AMP
Cyclic AMP - pharmacology
Enzyme activation
Enzyme Activation - drug effects
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Insulin - pharmacology
Isoproterenol - pharmacology
Kinetics
Mitogen stimulation
Mitogens - pharmacology
Phosphorylation
Protein Kinases - metabolism
Protein S6 kinase
Rats
Ribosomal Protein S6 Kinases
Transferases
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Summary:Forskolin and isoproterenol, agonists of adenylate cyclase activity, and dibutyryl cyclic AMP, stimulated an S6 kinase activity in astroglial cells. This activity was insensitive to the thermostable inhibitor of cyclic AMP-dependent protein kinase and had the same behaviour on a DEAE-Sephacel column as the mitogen stimulated S6 kinase. These observations support the idea that the cyclic AMP cascade, as well as various growth factors, can activate S6 kinase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80002-4