Identification of a major co-receptor for primary isolates of HIV-1

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, whic...

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Bibliographic Details
Published in:Nature (London) 1996-06, Vol.381 (6584), p.661-666
Main Authors: Deng, HongKui, Liu, Rong, Ellmeier, Wilfried, Choe, Sunny, Unutmaz, Derya, Burkhart, Michael, Marzio, Paola Di, Marmon, Shoshana, Sutton, Richard E, Hill, C. Mark, Davis, Craig B, Peiper, Stephen C, Schall, Thomas J, Littman, Dan R, Landau, Nathaniel R
Format: Article
Language:English
Subjects:
3T3 Cells
AIDS/HIV
Animals
Biochemistry
Biological and medical sciences
CD4 Antigens - metabolism
Cell Line
Chemokines - metabolism
Chemokines - physiology
DNA
Fundamental and applied biological sciences. Psychology
Gene Products, env - metabolism
Glycoproteins
HeLa Cells
HIV
HIV-1 - physiology
Human immunodeficiency virus
human immunodeficiency virus 1
Humanities and Social Sciences
Humans
letter
Macrophages - immunology
Macrophages - virology
Medical research
Membrane Fusion
Membrane Proteins - metabolism
Mice
Microbiology
Molecular Sequence Data
multidisciplinary
Proteins
Receptors, CCR5
Receptors, CXCR4
Receptors, Cytokine - genetics
Receptors, Cytokine - metabolism
Receptors, HIV - genetics
Receptors, HIV - metabolism
Recombinant Proteins - metabolism
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Science
Science (multidisciplinary)
T-Lymphocytes - immunology
T-Lymphocytes - virology
Virology
Virus Replication
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Description
Summary:Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo . The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.
ISSN:0028-0836
1476-4687
DOI:10.1038/381661a0