Multiple endocrine neoplasia type i with Cushing's disease, primary hyperparathyroidism, and insulin‐glucagonoma

A case of multiple endocrine neoplasia type I (MEN I) consisting of Cushing's disease, primary hyperparathyroidism, and insulin‐glucagonoma is described. This condition was treated successfully by transsphenoidal pituitary adenomectomy, subtotal parathyroidectomy, and enucleation of pancreatic...

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Bibliographic Details
Published in:Cancer 1988-03, Vol.61 (6), p.1232-1236
Main Authors: Miyagawa, Kiyoshi, Ishibashi, Miyuki, Kasuga, Masato, Kanazawa, Yasunori, Yamaji, Tohru, Takaku, Fumimaro
Format: Article
Language:English
Subjects:
Adenoma, Islet Cell - diagnosis
Adult
Biological and medical sciences
Cushing Syndrome - diagnosis
Endocrinopathies
Female
General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes
Humans
Hyperparathyroidism - diagnosis
Insulinoma - diagnosis
Medical sciences
Multiple Endocrine Neoplasia - diagnosis
Pancreatic Neoplasms - diagnosis
Retrospective Studies
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Description
Summary:A case of multiple endocrine neoplasia type I (MEN I) consisting of Cushing's disease, primary hyperparathyroidism, and insulin‐glucagonoma is described. This condition was treated successfully by transsphenoidal pituitary adenomectomy, subtotal parathyroidectomy, and enucleation of pancreatic tumors. Histologic features showed a basophilic adenoma in the pituitary, chief cell hyperplasia in the parathyroid, and islet cell adenomas in the pancreas. The rarity of multiple endocrine hyperfunctioning states and the pathophysiology created by the combination of these three diseases in this patient are of interest.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19880315)61:6<1232::AID-CNCR2820610629>3.0.CO;2-4