Dose-response, meal-stimulated gastric antisecretory study of prostaglandin E1 analog, misoprostol, in man

In a randomized, double-blind, crossover trial, the effects of 50-, 100-, and 200-micrograms doses of misoprostol on meal-stimulated gastric acid secretion were compared with placebo in 16 healthy male subjects. Compared with placebo, the 100- and 200-microgram doses produced significant reductions...

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Bibliographic Details
Published in:Digestive diseases and sciences 1988-03, Vol.33 (3), p.298-302
Main Authors: Davis, G R, Fordtran, J S, Dajani, E Z
Format: Article
Language:English
Subjects:
Adult
Alprostadil - administration & dosage
Alprostadil - adverse effects
Alprostadil - analogs & derivatives
Alprostadil - pharmacology
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - adverse effects
Anti-Ulcer Agents - pharmacology
Dose-Response Relationship, Drug
Double-Blind Method
Drug Evaluation
Food
Gastric Acid - metabolism
Gastrins - blood
Humans
Male
Misoprostol
Random Allocation
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Summary:In a randomized, double-blind, crossover trial, the effects of 50-, 100-, and 200-micrograms doses of misoprostol on meal-stimulated gastric acid secretion were compared with placebo in 16 healthy male subjects. Compared with placebo, the 100- and 200-microgram doses produced significant reductions in acid output for 2 and 3 hr, respectively, following the test meal (P = 0.05). Misoprostol did not influence either the fasting or postprandial serum gastrin levels as compared with placebo. No adverse experiences were reported by any of the subjects. One subject experienced a transient rise in SGPT as compared with baseline, which may have been due to ethanol intake. This study provides a scientific rationale on which to base additional trials of misoprostol in patients with disease related to gastric acid production.
ISSN:0163-2116
DOI:10.1007/BF01535753