Induction of endothelial cell differentiation into capillary-like structures by substance P

Angiogenesis is an important process in inflammatory diseases and wound healing. We observed that the proinflammatory neuropeptide, substance P, stimulated angiogenesis in an in vitro model using human umbilical cord vein endothelial cells cultured on a basement membrane (Matrigel) substrate. Substa...

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Bibliographic Details
Published in:European journal of pharmacology 1996-03, Vol.298 (3), p.335-338
Main Authors: Wiedermann, Christian J., Auer, Brigitte, Sitte, Birgit, Reinisch, Norbert, Schratzberger, Peter, Kähler, Christian M.
Format: Article
Language:English
Subjects:
Angiogenesis
Basement membrane
Basement Membrane - drug effects
Biological and medical sciences
Blood vessels and receptors
Capillaries - cytology
Capillaries - drug effects
Cell Differentiation - drug effects
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Neovascularization, Pathologic - chemically induced
Neovascularization, Pathologic - pathology
Neurogenic inflammation
Substance P - pharmacology
Tachykinin
Umbilical Veins - cytology
Umbilical Veins - drug effects
Vertebrates: cardiovascular system
Wound healing
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Summary:Angiogenesis is an important process in inflammatory diseases and wound healing. We observed that the proinflammatory neuropeptide, substance P, stimulated angiogenesis in an in vitro model using human umbilical cord vein endothelial cells cultured on a basement membrane (Matrigel) substrate. Substance P stimulated endothelial cell differentiation into capillary-like structures in a dose-dependent manner. Stimulation of endothelial cell differentiation is a newly recognized biological function of substance P. The increased levels of substance P found in chronic inflammatory conditions may play an important role in tissue repair by promoting the development of new vessels and thus achieving compensation for ischemia.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(95)00818-7