Developmental Down-Regulation of LTD in Cortical Layer IV and Its Independence of Modulation by Inhibition

For in vitro LTD to remain viable as a model for synaptic weakening in visual cortical plasticity, it is crucial that it display a critical period for its induction within layer IV. A complicating factor, however, is that LTD in layer IV is modulated by inhibitory postsynaptic potentials (IPSPs); po...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1996-06, Vol.16 (6), p.1097-1106
Main Authors: Dudek, Serena M, Friedlander, Michael J
Format: Article
Language:English
Subjects:
Animals
Cats
Down-Regulation
Guinea Pigs
Leukotriene D4 - physiology
Mammalia
Microscopy, Electron
Neuronal Plasticity - physiology
Neurons - physiology
Neurons - ultrastructure
Visual Cortex - physiology
Visual Pathways - physiology
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Summary:For in vitro LTD to remain viable as a model for synaptic weakening in visual cortical plasticity, it is crucial that it display a critical period for its induction within layer IV. A complicating factor, however, is that LTD in layer IV is modulated by inhibitory postsynaptic potentials (IPSPs); postsynaptic responses characterized as containing IPSPs do not depress in response to 1 Hz afferent stimulation. By blocking IPSPs intracellularly, we find that the ability to induce LTD in layer IV neurons is restored in juvenile, but not in mature animals. This developmental down-regulation of LTD induction is specific for layer IV when compared with LTD induction in layers II/III. These data are consistent with the hypothesis that an LTD-like phenomenon is involved in critical period plasticity and is apparently independent of developmental changes in inhibitory circuitry.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)80136-1