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Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus
Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was...
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| Published in: | The Journal of infectious diseases 1996-07, Vol.174 (1), p.46-53 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| container_end_page | 53 |
| container_issue | 1 |
| container_start_page | 46 |
| container_title | The Journal of infectious diseases |
| container_volume | 174 |
| creator | Chougnet, Claire Wynn, Thomas A. Clerici, Mario Landay, Alan L. Kessler, Harold A. Rusnak, Janice Melcher, Gregory P. Sher, Alan Shearer, Gene M. |
| description | Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively reduced than p40mRNA expression at these early stages. Monocytes infected in vitro with HIV displayed decreased p35 expression and p70 production, suggesting that such decreased IL-12 expression may contribute to reduced IL-12 production in HIV-positive patients' cells. In addition, treatment of cells with IL-10 increased IL-10 mRNA expression and decreased p40 expression in both HIV-positive and -negative cells, while neutralization of IL-10 increased p40 mRNA levels. These observations, together with the observed hyperproduction of IL-10 in HIV-positive patients, may explain the dysregulation of IL-12 production seen in HIV disease. |
| doi_str_mv | 10.1093/infdis/174.1.46 |
| format | article |
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The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively reduced than p40mRNA expression at these early stages. Monocytes infected in vitro with HIV displayed decreased p35 expression and p70 production, suggesting that such decreased IL-12 expression may contribute to reduced IL-12 production in HIV-positive patients' cells. In addition, treatment of cells with IL-10 increased IL-10 mRNA expression and decreased p40 expression in both HIV-positive and -negative cells, while neutralization of IL-10 increased p40 mRNA levels. These observations, together with the observed hyperproduction of IL-10 in HIV-positive patients, may explain the dysregulation of IL-12 production seen in HIV disease.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/174.1.46</identifier><identifier>PMID: 8656012</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS ; AIDS/HIV ; Antigen presenting cells ; Base Sequence ; Biological and medical sciences ; Blood ; Cytokines ; Gene expression regulation ; Gene Expression Regulation, Viral ; HIV ; HIV Infections - metabolism ; human immunodeficiency virus ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Interleukin-10 - biosynthesis ; Interleukin-10 - genetics ; Interleukin-10 - physiology ; Interleukin-12 - biosynthesis ; Interleukin-12 - genetics ; Major Articles ; Medical sciences ; Messenger RNA ; Molecular Sequence Data ; Monocytes ; Peripheral blood mononuclear cells ; RNA, Messenger - blood ; T lymphocytes</subject><ispartof>The Journal of infectious diseases, 1996-07, Vol.174 (1), p.46-53</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>1996 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jul 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-2699c989959bc29cf19256d8787df69dcc7074f544399f754a7468686c41ffab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30126217$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30126217$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3133189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8656012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chougnet, Claire</creatorcontrib><creatorcontrib>Wynn, Thomas A.</creatorcontrib><creatorcontrib>Clerici, Mario</creatorcontrib><creatorcontrib>Landay, Alan L.</creatorcontrib><creatorcontrib>Kessler, Harold A.</creatorcontrib><creatorcontrib>Rusnak, Janice</creatorcontrib><creatorcontrib>Melcher, Gregory P.</creatorcontrib><creatorcontrib>Sher, Alan</creatorcontrib><creatorcontrib>Shearer, Gene M.</creatorcontrib><title>Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively reduced than p40mRNA expression at these early stages. Monocytes infected in vitro with HIV displayed decreased p35 expression and p70 production, suggesting that such decreased IL-12 expression may contribute to reduced IL-12 production in HIV-positive patients' cells. In addition, treatment of cells with IL-10 increased IL-10 mRNA expression and decreased p40 expression in both HIV-positive and -negative cells, while neutralization of IL-10 increased p40 mRNA levels. These observations, together with the observed hyperproduction of IL-10 in HIV-positive patients, may explain the dysregulation of IL-12 production seen in HIV disease.</description><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antigen presenting cells</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cytokines</subject><subject>Gene expression regulation</subject><subject>Gene Expression Regulation, Viral</subject><subject>HIV</subject><subject>HIV Infections - metabolism</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - physiology</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Interleukin-12 - genetics</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>Monocytes</subject><subject>Peripheral blood mononuclear cells</subject><subject>RNA, Messenger - blood</subject><subject>T lymphocytes</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkUFvEzEQRi0EKiFw5oS0QojbJh7ba6-PVSkkqBU5FIS4WI7XFk537dbeVcm_xyWhlbigOczhPX8a-UPoNeAFYEmXPrjO5yUItoAF40_QDBoqas6BPkUzjAmpoZXyOXqR8w5jzCgXJ-ik5Q3HQGYoXsbemqnXqToNut9nn6voqg_WJKuz7ap1GG3q7XTtQw2k2qTYTWb0MVQ-VBubcgy5SM6asdh3fvxZraZBh2o9DFOInXXeeBvMvvrm05RfomdO99m-Ou45-vrx_OpsVV98-bQ-O72oDWvxWBMupZHl8EZuDZHGgSQN71rRis5x2RkjsGCuYYxK6UTDtGC8LWMYOKe3dI7eH3JvUrydbB7V4LOxfa-DjVNWogXAjNP_itBwaEl7L779R9zFKZU_y4oQKkHwP2nLg2RSzDlZp26SH3TaK8DqvjB1KEyVwhSocsAcvTnGTtvBdg_-saHC3x25zkb3Lulgyvu_GgVKS8GPMbs8xvSISwQnIAqvD9zn0f564DpdKy6oaNTq-w8lN5dXElYr9Zn-BlAZt1U</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Chougnet, Claire</creator><creator>Wynn, Thomas A.</creator><creator>Clerici, Mario</creator><creator>Landay, Alan L.</creator><creator>Kessler, Harold A.</creator><creator>Rusnak, Janice</creator><creator>Melcher, Gregory P.</creator><creator>Sher, Alan</creator><creator>Shearer, Gene M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus</title><author>Chougnet, Claire ; Wynn, Thomas A. ; Clerici, Mario ; Landay, Alan L. ; Kessler, Harold A. ; Rusnak, Janice ; Melcher, Gregory P. ; Sher, Alan ; Shearer, Gene M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-2699c989959bc29cf19256d8787df69dcc7074f544399f754a7468686c41ffab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antigen presenting cells</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cytokines</topic><topic>Gene expression regulation</topic><topic>Gene Expression Regulation, Viral</topic><topic>HIV</topic><topic>HIV Infections - metabolism</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - physiology</topic><topic>Interleukin-12 - biosynthesis</topic><topic>Interleukin-12 - genetics</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Messenger RNA</topic><topic>Molecular Sequence Data</topic><topic>Monocytes</topic><topic>Peripheral blood mononuclear cells</topic><topic>RNA, Messenger - blood</topic><topic>T lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chougnet, Claire</creatorcontrib><creatorcontrib>Wynn, Thomas A.</creatorcontrib><creatorcontrib>Clerici, Mario</creatorcontrib><creatorcontrib>Landay, Alan L.</creatorcontrib><creatorcontrib>Kessler, Harold A.</creatorcontrib><creatorcontrib>Rusnak, Janice</creatorcontrib><creatorcontrib>Melcher, Gregory P.</creatorcontrib><creatorcontrib>Sher, Alan</creatorcontrib><creatorcontrib>Shearer, Gene M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chougnet, Claire</au><au>Wynn, Thomas A.</au><au>Clerici, Mario</au><au>Landay, Alan L.</au><au>Kessler, Harold A.</au><au>Rusnak, Janice</au><au>Melcher, Gregory P.</au><au>Sher, Alan</au><au>Shearer, Gene M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>174</volume><issue>1</issue><spage>46</spage><epage>53</epage><pages>46-53</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively reduced than p40mRNA expression at these early stages. Monocytes infected in vitro with HIV displayed decreased p35 expression and p70 production, suggesting that such decreased IL-12 expression may contribute to reduced IL-12 production in HIV-positive patients' cells. In addition, treatment of cells with IL-10 increased IL-10 mRNA expression and decreased p40 expression in both HIV-positive and -negative cells, while neutralization of IL-10 increased p40 mRNA levels. 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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1996-07, Vol.174 (1), p.46-53 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78110463 |
| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | AIDS AIDS/HIV Antigen presenting cells Base Sequence Biological and medical sciences Blood Cytokines Gene expression regulation Gene Expression Regulation, Viral HIV HIV Infections - metabolism human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-10 - physiology Interleukin-12 - biosynthesis Interleukin-12 - genetics Major Articles Medical sciences Messenger RNA Molecular Sequence Data Monocytes Peripheral blood mononuclear cells RNA, Messenger - blood T lymphocytes |
| title | Molecular Analysis of Decreased Interleukin-12 Production in Persons Infected with Human Immunodeficiency Virus |
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