t(4;19)(q35;q13.1): A recurrent change in primitive mesenchymal tumors?

We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1996-03, Vol.87 (1), p.71-74
Main Authors: Richkind, K.E., Romansky, S.G., Finklestein, J.Z.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 4
Dermatology
Humans
Male
Medical sciences
Rhabdomyosarcoma - genetics
Sarcoma - chemistry
Sarcoma - genetics
Sarcoma - pathology
Soft Tissue Neoplasms - chemistry
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Translocation, Genetic
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(95)00240-5