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t(4;19)(q35;q13.1): A recurrent change in primitive mesenchymal tumors?

We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic...

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Published in:	Cancer genetics and cytogenetics 1996-03, Vol.87 (1), p.71-74
Main Authors:	Richkind, K.E., Romansky, S.G., Finklestein, J.Z.
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Child Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 4 Dermatology Humans Male Medical sciences Rhabdomyosarcoma - genetics Sarcoma - chemistry Sarcoma - genetics Sarcoma - pathology Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Translocation, Genetic Tumors of the skin and soft tissue. Premalignant lesions
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creator	Richkind, K.E. Romansky, S.G. Finklestein, J.Z.
description	We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.
doi_str_mv	10.1016/0165-4608(95)00240-5
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Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(95)00240-5</identifier><identifier>PMID: 8646746</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Child ; Chromosomes, Human, Pair 19 ; Chromosomes, Human, Pair 4 ; Dermatology ; Humans ; Male ; Medical sciences ; Rhabdomyosarcoma - genetics ; Sarcoma - chemistry ; Sarcoma - genetics ; Sarcoma - pathology ; Soft Tissue Neoplasms - chemistry ; Soft Tissue Neoplasms - genetics ; Soft Tissue Neoplasms - pathology ; Translocation, Genetic ; Tumors of the skin and soft tissue. 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Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Chromosomes, Human, Pair 4</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rhabdomyosarcoma - genetics</subject><subject>Sarcoma - chemistry</subject><subject>Sarcoma - genetics</subject><subject>Sarcoma - pathology</subject><subject>Soft Tissue Neoplasms - chemistry</subject><subject>Soft Tissue Neoplasms - genetics</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Translocation, Genetic</subject><subject>Tumors of the skin and soft tissue. 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Premalignant lesions</topic><toplevel>online_resources</toplevel><creatorcontrib>Richkind, K.E.</creatorcontrib><creatorcontrib>Romansky, S.G.</creatorcontrib><creatorcontrib>Finklestein, J.Z.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richkind, K.E.</au><au>Romansky, S.G.</au><au>Finklestein, J.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>t(4;19)(q35;q13.1): A recurrent change in primitive mesenchymal tumors?</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>87</volume><issue>1</issue><spage>71</spage><epage>74</epage><pages>71-74</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We report an apparently balanced t(4;19)(q35;q13.1) as the sole cytogenetic change in a highly malignant extraskeletal sarcoma in a 12-year-old-boy. Tumor cells were negative for all immunocytochemical markers except vimentin and neuron-specific enolase. Electron microscopy indicated chondroblastic differentiation. The tumor was categorized as a malignant sarcoma with differentiation toward extraskeletal mesenchymal chondrosarcoma. Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8646746</pmid><doi>10.1016/0165-4608(95)00240-5</doi><tpages>4</tpages></addata></record>
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subjects	Biological and medical sciences Child Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 4 Dermatology Humans Male Medical sciences Rhabdomyosarcoma - genetics Sarcoma - chemistry Sarcoma - genetics Sarcoma - pathology Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Translocation, Genetic Tumors of the skin and soft tissue. Premalignant lesions
title	t(4;19)(q35;q13.1): A recurrent change in primitive mesenchymal tumors?
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