Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression

A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) pre...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-07, Vol.174 (1), p.199-203
Main Authors: Intrieri, Mariano, Calcagno, Giuseppe, Oriani, Giovannangelo, Pane, Fabrizio, Zarrilli, Federica, Cataldo, Pietro Tullio, Foggia, Maria, Piazza, Marcello, Salvatore, Francesco, Sacchetti, Lucia
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - virology
Adult
AIDS
AIDS/HIV
beta 2-Microglobulin - metabolism
Biological and medical sciences
CD4-CD8 Ratio
Concise Communications
Disease Progression
Female
HIV
HIV infections
HIV-1
human immunodeficiency virus 1
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Lymphocytes
Male
Medical sciences
Middle Aged
Nucleosides
Odds Ratio
Permanence
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Pseudouridine - blood
Pyridones - blood
Ribonucleosides - blood
T lymphocytes
Time Factors
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Summary:A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29–6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and Prmicroglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/174.1.199