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Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression
A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) pre...
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| Published in: | The Journal of infectious diseases 1996-07, Vol.174 (1), p.199-203 |
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| container_end_page | 203 |
| container_issue | 1 |
| container_start_page | 199 |
| container_title | The Journal of infectious diseases |
| container_volume | 174 |
| creator | Intrieri, Mariano Calcagno, Giuseppe Oriani, Giovannangelo Pane, Fabrizio Zarrilli, Federica Cataldo, Pietro Tullio Foggia, Maria Piazza, Marcello Salvatore, Francesco Sacchetti, Lucia |
| description | A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29–6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and Prmicroglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters). |
| doi_str_mv | 10.1093/infdis/174.1.199 |
| format | article |
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Serum concentrations of pseudouridine (>3.77 nmollmL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29–6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and Prmicroglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/174.1.199</identifier><identifier>PMID: 8655995</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - virology ; Adult ; AIDS ; AIDS/HIV ; beta 2-Microglobulin - metabolism ; Biological and medical sciences ; CD4-CD8 Ratio ; Concise Communications ; Disease Progression ; Female ; HIV ; HIV infections ; HIV-1 ; human immunodeficiency virus 1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Lymphocytes ; Male ; Medical sciences ; Middle Aged ; Nucleosides ; Odds Ratio ; Permanence ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Pseudouridine - blood ; Pyridones - blood ; Ribonucleosides - blood ; T lymphocytes ; Time Factors</subject><ispartof>The Journal of infectious diseases, 1996-07, Vol.174 (1), p.199-203</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-694f94e810f701d5a1ea7e61d010db60201bc336351b0812a107246465f3f2693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30126240$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30126240$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3135374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8655995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Intrieri, Mariano</creatorcontrib><creatorcontrib>Calcagno, Giuseppe</creatorcontrib><creatorcontrib>Oriani, Giovannangelo</creatorcontrib><creatorcontrib>Pane, Fabrizio</creatorcontrib><creatorcontrib>Zarrilli, Federica</creatorcontrib><creatorcontrib>Cataldo, Pietro Tullio</creatorcontrib><creatorcontrib>Foggia, Maria</creatorcontrib><creatorcontrib>Piazza, Marcello</creatorcontrib><creatorcontrib>Salvatore, Francesco</creatorcontrib><creatorcontrib>Sacchetti, Lucia</creatorcontrib><title>Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29–6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and Prmicroglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>beta 2-Microglobulin - metabolism</subject><subject>Biological and medical sciences</subject><subject>CD4-CD8 Ratio</subject><subject>Concise Communications</subject><subject>Disease Progression</subject><subject>Female</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV-1</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nucleosides</subject><subject>Odds Ratio</subject><subject>Permanence</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Pseudouridine - blood</subject><subject>Pyridones - blood</subject><subject>Ribonucleosides - blood</subject><subject>T lymphocytes</subject><subject>Time Factors</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFks1uEzEUhUcIVNLCng2SFwjBYlLf8c_MLNNQSNSKRk2pEBvLM76DXDJ2sGek5tl4OQwJ7ZKNLd3vnHMlH2fZK6BToDU7ta4zNp5Cyacwhbp-kk1AsDKXEtjTbEJpUeRQ1fXz7DjGO0opZ7I8yo4qKURdi0n2axVxNH4M1liHRDtDIL-2jY-7zXb3d5rz_MphzvK5Do2_1701SN6t5p-v35M1hrEnc-9adEPQg_UuEuvIYuy1I8u-H5032NnWomt35NaGMZKb3RbTlqXrsB3QkFXyJXsks4Bk6QxuMR1uIKuAxraDD5F0PpDZ8sM6zfz3gDGmTS-yZ53eRHx5uE-yLx_Pb-aL_PLq03I-u8xbLqohlzXvao4V0K6kYIQG1CVKMBSoaSQtKDQtY5IJaGgFhQZaFlxyKTrWFbJmJ9nbfe42-J8jxkH1Nra42WiHfoyqrAAEQPVfIQgJFRcsCele2AYfY8BObYPtddgpoOpPsWpfrErFKlCp2GR5fcgemx7Ng-HQZOJvDlzHVm-6oF2bAv7JGLD0L_hjzF1M7_qIKRSy4DTxfM9tHPD-gevwQ8mSlUItvn5T64tbXl_IMyXYb7ijxiw</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Intrieri, Mariano</creator><creator>Calcagno, Giuseppe</creator><creator>Oriani, Giovannangelo</creator><creator>Pane, Fabrizio</creator><creator>Zarrilli, Federica</creator><creator>Cataldo, Pietro Tullio</creator><creator>Foggia, Maria</creator><creator>Piazza, Marcello</creator><creator>Salvatore, Francesco</creator><creator>Sacchetti, Lucia</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression</title><author>Intrieri, Mariano ; Calcagno, Giuseppe ; Oriani, Giovannangelo ; Pane, Fabrizio ; Zarrilli, Federica ; Cataldo, Pietro Tullio ; Foggia, Maria ; Piazza, Marcello ; Salvatore, Francesco ; Sacchetti, Lucia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-694f94e810f701d5a1ea7e61d010db60201bc336351b0812a107246465f3f2693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>beta 2-Microglobulin - metabolism</topic><topic>Biological and medical sciences</topic><topic>CD4-CD8 Ratio</topic><topic>Concise Communications</topic><topic>Disease Progression</topic><topic>Female</topic><topic>HIV</topic><topic>HIV infections</topic><topic>HIV-1</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nucleosides</topic><topic>Odds Ratio</topic><topic>Permanence</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Pseudouridine - blood</topic><topic>Pyridones - blood</topic><topic>Ribonucleosides - blood</topic><topic>T lymphocytes</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Intrieri, Mariano</creatorcontrib><creatorcontrib>Calcagno, Giuseppe</creatorcontrib><creatorcontrib>Oriani, Giovannangelo</creatorcontrib><creatorcontrib>Pane, Fabrizio</creatorcontrib><creatorcontrib>Zarrilli, Federica</creatorcontrib><creatorcontrib>Cataldo, Pietro Tullio</creatorcontrib><creatorcontrib>Foggia, Maria</creatorcontrib><creatorcontrib>Piazza, Marcello</creatorcontrib><creatorcontrib>Salvatore, Francesco</creatorcontrib><creatorcontrib>Sacchetti, Lucia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Intrieri, Mariano</au><au>Calcagno, Giuseppe</au><au>Oriani, Giovannangelo</au><au>Pane, Fabrizio</au><au>Zarrilli, Federica</au><au>Cataldo, Pietro Tullio</au><au>Foggia, Maria</au><au>Piazza, Marcello</au><au>Salvatore, Francesco</au><au>Sacchetti, Lucia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>174</volume><issue>1</issue><spage>199</spage><epage>203</epage><pages>199-203</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (>3.77 nmollmL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29–6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and Prmicroglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8655995</pmid><doi>10.1093/infdis/174.1.199</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1996-07, Vol.174 (1), p.199-203 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78115118 |
| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - virology Adult AIDS AIDS/HIV beta 2-Microglobulin - metabolism Biological and medical sciences CD4-CD8 Ratio Concise Communications Disease Progression Female HIV HIV infections HIV-1 human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Lymphocytes Male Medical sciences Middle Aged Nucleosides Odds Ratio Permanence Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Pseudouridine - blood Pyridones - blood Ribonucleosides - blood T lymphocytes Time Factors |
| title | Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS Progression |
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