Generation and recognition of leukotriene mediators of hypersensitivity and inflammation

The potent mediators generated by the 5- and 15-lipoxygenation of arachidonic acid have diverse effects on smooth muscles, blood vessels, leukocytes, epithelial cells and glands, and sensory neurons, which suggest possible roles in the initiation and regulation of physiological and biochemical event...

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Bibliographic Details
Published in:Digestive diseases and sciences 1988-03, Vol.33 (3 Suppl), p.36S-40S
Main Authors: Goetzl, E J, Burrall, B A, Baud, L, Scriven, K H, Levine, J D, Koo, C H
Format: Article
Language:English
Subjects:
Arachidonate 15-Lipoxygenase - physiology
Arachidonate 5-Lipoxygenase - physiology
Colitis, Ulcerative - etiology
Crohn Disease - etiology
Humans
Hypersensitivity - etiology
Inflammation - etiology
Leukotriene B4 - physiology
SRS-A - physiology
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Summary:The potent mediators generated by the 5- and 15-lipoxygenation of arachidonic acid have diverse effects on smooth muscles, blood vessels, leukocytes, epithelial cells and glands, and sensory neurons, which suggest possible roles in the initiation and regulation of physiological and biochemical events. The responses to leukotrienes and related mediators are attributable to binding by stereospecific cellular receptors and consequent activation of biochemical transductional sequences analogous to those characteristic of other receptor systems. The elevated concentrations of these mediators in lesional fluids and tissues of inflammatory bowel disease and other hypersensitivity and inflammatory states are, in some instances, clearly related to the time course of development of the disease process. Systematic application of specific inhibitors and antagonists that are becoming available will define more clearly the involvement of leukotrienes in health and disease and possibly lead to new therapeutic approaches.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01538129