Oral calcium loading test and response to diuretics in normal Taiwanese school children

To investigate possible mechanisms of increased urinary calcium excretion and increased prevalence of urolithiasis in 16- to 20-year-old children, oral calcium loading and diuretic tests were performed in 120 normal children in three age groups (7-8, 12-13, and 17-18 years of age). Urinary calcium/c...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1996-04, Vol.10 (2), p.175-179
Main Authors: Chen, Y H, Lee, A J, Lin, C S, Chen, C H, Chesney, R W, Stapleton, F B, Roy, 3rd, S
Format: Article
Language:English
Subjects:
Acetazolamide - pharmacology
Administration, Oral
Adolescent
Calcium - urine
Calcium, Dietary - administration & dosage
Child
Creatinine - urine
Diuretics - pharmacology
Furosemide - pharmacology
Humans
Hydrochlorothiazide - pharmacology
Kidney - drug effects
Kidney - metabolism
Reference Values
Schools
Taiwan
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Summary:To investigate possible mechanisms of increased urinary calcium excretion and increased prevalence of urolithiasis in 16- to 20-year-old children, oral calcium loading and diuretic tests were performed in 120 normal children in three age groups (7-8, 12-13, and 17-18 years of age). Urinary calcium/creatinine ratios and 24-h urinary calcium excretion were significantly increased following the oral calcium loading test in 17- to 18-year-olds compared with the two younger age groups. Oral furosemide resulted in increased urinary calcium excretion in the 17- to 18-year age group, while hydrochlorothiazide was less effective in reducing urinary calcium excretion in this age group. These results suggest that increased intestinal calcium absorption and decreased renal tubular reabsorption of calcium in 17- to 18-year-olds may be contributing factors in the increased prevalence of nephrolithiasis in older Taiwanese children.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00862067