Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol [( 3H]-DHA) decreased significantly in fronta...

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Bibliographic Details
Published in:Psychopharmacologia 1988-01, Vol.94 (1), p.141-143
Main Authors: BYERLEY, W. F, MCCONNELL, E. J, MCCABE, R. T, DAWSON, T. M, GROSSER, B. I, WAMSLEY, J. K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Dihydroalprenolol
Fluoxetine - pharmacology
Kinetics
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Propylamines - pharmacology
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta - metabolism
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Summary:Fluoxetine, a novel antidepressant compound that potently and selectively inhibits serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]-dihydroalprenolol [( 3H]-DHA) decreased significantly in frontal cortex layers. Analysis of saturation experiments indicated that the reduction was due to a change in number but not affinity of [3H]-DHA binding sites. The data support the hypothesis that the mechanism of action of most antidepressant compounds involves a change in beta-adrenergic receptor function.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00735896