Immune infiltrates and cytokines in gliomas

Frozen sections of 21 gliomas were analysed to characterize inflammatory infiltrating cells, HLA-DR antigen expression and cytokine secretion. Mononuclear cells infiltrating the tumours were mostly macrophages, which were detected in 100% of cases, and expressed HLA-DR antigens. Lymphocytes were les...

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Bibliographic Details
Published in:Acta neurochirurgica 1996, Vol.138 (1), p.50-56
Main Authors: GIOMETTO, B, BOZZA, F, FARESIN, F, ALESSIO, L, MINGRINO, S, TAVOLATO, B
Format: Article
Language:English
Subjects:
Astrocytes - immunology
Astrocytes - pathology
Biological and medical sciences
Brain - immunology
Brain - pathology
Brain - surgery
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Cell Transformation, Neoplastic - immunology
Cell Transformation, Neoplastic - pathology
Craniotomy
Cytokines - analysis
Glioblastoma - immunology
Glioblastoma - pathology
Glioblastoma - surgery
HLA-DR Antigens - analysis
Humans
Immunity, Cellular - immunology
Immunoenzyme Techniques
Interleukin-1 - analysis
Interleukin-6 - analysis
Lymphocyte Subsets - immunology
Lymphocyte Subsets - pathology
Macrophages - immunology
Macrophages - pathology
Medical sciences
Monocytes - immunology
Monocytes - pathology
Neurology
Prognosis
Tumors of the nervous system. Phacomatoses
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Summary:Frozen sections of 21 gliomas were analysed to characterize inflammatory infiltrating cells, HLA-DR antigen expression and cytokine secretion. Mononuclear cells infiltrating the tumours were mostly macrophages, which were detected in 100% of cases, and expressed HLA-DR antigens. Lymphocytes were less frequently seen and expressed the CD8 phenotype. Interleukin-1 beta (IL-1 beta) and Interleukin-6 (IL-6), two cytokines mainly produced by activated cells of the macrophage lineage, were demonstrated especially in neoplastic astrocytes. IL-1 beta immunoreactivity was detected in all tumours, and was prevalent in more anaplastic gliomas; IL-6 was found in anaplastic gliomas and in glioblastomas. IL-1 receptors were expressed by both infiltrating macrophages and neoplastic astrocytes in the gliomas analysed. These findings suggest that cytokine production in gliomas seems not related to immune reactions against the tumour and their synthesis by anaplastic astrocytes could follow an unregulated activation of many metabolic processes after neoplastic transformation.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01411724