The economics of neurite outgrowth — the addition of new membrane to growing axons

Recent studies have shown that axonal growth is disrupted by treatments that block the synthesis of membrane components or their delivery by microtubule-based transport. This implies that a continuous supply of newly synthesized membrane components is necessary to sustain growth. In contrast, no cle...

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Bibliographic Details
Published in:Trends in Neurosciences 1996-04, Vol.19 (4), p.144-149
Main Authors: Futerman, Anthony H., Banker, Gary A.
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Axons - ultrastructure
Biological and medical sciences
Cell Division - physiology
Cell Membrane - physiology
Cellular biology
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Membranes
Neurites - physiology
Neurology
Neurons
Neurons - cytology
Neurons - ultrastructure
Vertebrates: nervous system and sense organs
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Summary:Recent studies have shown that axonal growth is disrupted by treatments that block the synthesis of membrane components or their delivery by microtubule-based transport. This implies that a continuous supply of newly synthesized membrane components is necessary to sustain growth. In contrast, no clear consensus has yet been achieved about the site of insertion of new membrane components in the membrane of the growing axon, despite the application of new and refined biophysical and molecular techniques to the study of this issue. Until the site of insertion of new membrane components is resolved, little progress can be made in defining the feedback mechanisms by which the supply of new membrane components is co-ordinated with the demands of growth, particularly in cases where the dynamics of neurite growth change from minute to minute.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(96)80025-7