Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments

REM sleep deprivation (REMSD) induces augmented responses to dopaminergic agonists. Prolonged administration of neuroleptics induces a similar state, probably by the production of supersensitivity of dopaminergic receptors. Such a supersensitive state could be induced by REMSD as a result of impairm...

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Bibliographic Details
Published in:Psychopharmacologia 1988-01, Vol.94 (1), p.79-83
Main Authors: TRONCONE, L. R. P, FERREIRA, T. M. S, BRAZ, S, SILVEIRA, N. G. FILHO, TUFIK, S
Format: Article
Language:English
Subjects:
Aggression - drug effects
Amphetamine - pharmacology
Animals
Apomorphine - pharmacology
Behavioral psychophysiology
Biological and medical sciences
Bromocriptine - pharmacology
Carbidopa - pharmacology
Dopamine - physiology
Fundamental and applied biological sciences. Psychology
Imipramine - pharmacology
Levodopa - pharmacology
Male
Nomifensine - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Inbred Strains
Sleep Deprivation - physiology
Sleep, REM - physiology
Stereotyped Behavior - drug effects
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Summary:REM sleep deprivation (REMSD) induces augmented responses to dopaminergic agonists. Prolonged administration of neuroleptics induces a similar state, probably by the production of supersensitivity of dopaminergic receptors. Such a supersensitive state could be induced by REMSD as a result of impairment of dopamine neurotransmission. In order to test this hypothesis, bromocriptine, nomifensine, amphetamine, L-dopa, imipramine and electroconvulsive shock (ECS) were administered to rats during REMSD, and aggressive and stereotyped behaviors were measured. Amphetamine and L-dopa pretreatment attenuated the increases in apomorphine-induced stereotypy and aggression in REMSD rats, but ECS selectively reduced apomorphine-induced aggression. The other drugs tested were ineffective on both behavioral tests. Such a selective action may reflect different effects of ECS on different dopaminergic systems such as those involved with stereotypy and aggression. The results suggest that REMSD induces an increase in dopaminergic sensitivity which may be reversed by pretreatment with some dopaminergic agonists.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00735885