The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein

In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevatio...

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Bibliographic Details
Published in:Archives of virology 1996-01, Vol.141 (5), p.791-800
Main Authors: CHEN, S.-L, HUANG, C.-H, TSAI, T.-C, LU, K.-Y, TSAO, Y.-P
Format: Article
Language:English
Subjects:
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell Division
Cells, Cultured
Gene Expression Regulation
Genes, jun
Humans
Isoquinolines - pharmacology
Keratinocytes - metabolism
Medical sciences
Oncogene Proteins, Viral - physiology
Piperazines - pharmacology
Simian virus 40
Sulfonamides
Tumors
Viruses
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Summary:In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01718155