Spatial learning in a Z-maze by cerebellar mutant mice

Two types of cerebellar mutant mice (staggerer and lurcher) were evaluated during 5-day acquisition of a spatial learning task in a Z-maze filled with water. Although the number of errors and escape latencies decreased in normal mice, the acquisition of the cerebellar mutants was impaired but not ab...

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Bibliographic Details
Published in:Physiology & behavior 1996, Vol.59 (1), p.83-86
Main Authors: Lalonde, R., Filali, M., Bensoula, A.N., Monnier, C., Guastavino, J.-M.
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
Behavioral psychophysiology
Biological and medical sciences
Cerebellar Diseases - genetics
Cerebellar mutants
Cerebellum
Female
Fundamental and applied biological sciences. Psychology
Male
Maze
Maze Learning - physiology
Mice
Mice, Neurologic Mutants
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Space Perception - physiology
Spatial learning
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Summary:Two types of cerebellar mutant mice (staggerer and lurcher) were evaluated during 5-day acquisition of a spatial learning task in a Z-maze filled with water. Although the number of errors and escape latencies decreased in normal mice, the acquisition of the cerebellar mutants was impaired but not abolished. These results indicate that the cerebellum has a role in spatial learning. Mice with cerebellar dysfunction take a more indirect route toward a goal during the course of swimming, when ataxic symptoms are no longer in evidence.
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(95)02041-1