Hydroxymycotrienins A and B, New Ansamycin Group Antibiotics

New ansamycins designated hydroxymycotrienins A and B were isolated from culture broths of Bacillus sp. BMJ958-62F4. The two antibiotics inhibited more strongly the growth of human cervical cancer cell lines of human papilloma virus (HPV) positive than that of HPV negative cell lines. The structures...

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Bibliographic Details
Published in:Journal of antibiotics 1996/05/25, Vol.49(5), pp.425-431
Main Authors: HOSOKAWA, NOBUO, NAGANAWA, HIROSHI, HAMADA, MASA, TAKEUCHI, TOMIO, IKENO, SOUICHI, HORI, MAKOTO
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antineoplastic agents
Bacillus
Base Sequence
Biological and medical sciences
Chemotherapy
Female
Fermentation
HeLa Cells - drug effects
Humans
Medical sciences
Molecular Sequence Data
Molecular Structure
Pharmacology. Drug treatments
Rifabutin - analogs & derivatives
Rifabutin - chemistry
Rifabutin - isolation & purification
Rifabutin - pharmacology
Tumor Cells, Cultured - drug effects
Uterine Cervical Neoplasms - drug therapy
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Summary:New ansamycins designated hydroxymycotrienins A and B were isolated from culture broths of Bacillus sp. BMJ958-62F4. The two antibiotics inhibited more strongly the growth of human cervical cancer cell lines of human papilloma virus (HPV) positive than that of HPV negative cell lines. The structures, some biological and biochemical properties are reported.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.49.425