T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens

T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a mod...

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Bibliographic Details
Published in:Nature (London) 1988-03, Vol.332 (6159), p.40-45
Main Authors: ROBSON MACDONALD, H, SCHNEIDER, R, LEES, R. K, HOWE, R. C, ACHA-ORBEA, H, FESTENSTEIN, H, ZINKERNAGEL, R. M, HENGARTNER, H
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Antigens, Surface - genetics
Antigens, Surface - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immune Tolerance
Immunobiology
Major Histocompatibility Complex
Mice
Mice, Inbred Strains
Minor Lymphocyte Stimulatory Antigens
Organs and cells involved in the immune response
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - immunology
T-Lymphocytes - immunology
Thymus Gland - immunology
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Summary:T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
ISSN:0028-0836
1476-4687
DOI:10.1038/332040a0