Relationship between serum levels of interleukin 6, various disease parameters, and malnutrition in patients with esophageal squamous cell carcinoma

Serum levels of interleukin 6 (IL-6) are correlated with the disease status and prognosis in cancer patients. IL-6 is also an important mediator of experimental cancer cachexia. We investigated the production of IL-6 and IL-6 receptors and expression of IL-6 mRNA by esophageal squamous carcinoma cel...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (12), p.2776-2780
Main Authors: OKA, M, YAMAMOTO, K, HIROSE, K, ISHIHARA, T, SUZUKI, T, TAKAHASHI, M, HAKOZAKI, M, ABE, T, IIZUKA, N, HAZAMA, S, HIRAZAWA, K, HAYASHI, H, TANGOKU, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, CD - metabolism
Base Sequence
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoma, Squamous Cell - blood
Esophageal Neoplasms - blood
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Neoplasm Proteins - blood
Nutrition Disorders - blood
Receptors, Interleukin - metabolism
Receptors, Interleukin-6
RNA, Messenger - blood
Tumors
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Summary:Serum levels of interleukin 6 (IL-6) are correlated with the disease status and prognosis in cancer patients. IL-6 is also an important mediator of experimental cancer cachexia. We investigated the production of IL-6 and IL-6 receptors and expression of IL-6 mRNA by esophageal squamous carcinoma cells using immunohistochemical staining and in situ reverse transcription-PCR. We also measured levels of serum IL-6 using an ELISA in 50 patients with esophageal squamous cell carcinoma (ESCC) to determine the correlation between serum levels of IL-6 and clinicopathological factors IL-6 mRNA was expressed in the primary tumor. Esophageal squamous carcinoma cells produced both IL-6 and IL-6 receptor. IL-6 concentrations were significantly higher in the primary tumor than in the normal epithelium. The incidences of weight loss, tumor invasion to adjacent organs, and noncurative resection were significantly higher in ESCC patients with serum levels of IL-6 > or = 7 pg/ml (n = 13, group C) compared with patients with serum levels or = 3 pg/ml (n = 14, group B) and
ISSN:0008-5472
1538-7445