Boundary and insulator elements in chromosomes

Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a ro...

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Bibliographic Details
Published in:Current opinion in genetics & development 1996-04, Vol.6 (2), p.185-192
Main Authors: Gerasimova, Tatiana I, Corces, Victor G
Format: Article
Language:English
Subjects:
Animals
Antigens, Nuclear
Chromosomes - chemistry
DNA-Binding Proteins - physiology
Drosophila
Enhancer Elements, Genetic - physiology
Gene Expression Regulation - physiology
Humans
Nuclear Proteins - physiology
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Summary:Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a role in the organization of structural chromosomal domains. The suppressor of Hairy-wing and modifier of modg4 proteins have been characterized as components of the gypsy insulator. The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(96)80049-9