Heparin-Binding Growth Factor/Prostatropin Attenuates Inhibition of Rat Prostate Tumor Epithelial Cell Growth by Transforming Growth Factor Type Beta

Normal rat prostate epithelial cell growth requires both epidermal growth factor and heparin-binding growth factor/prostatropin. In contrast, epithelial cells derived from the transplantable Dunning R3327H rat tumor require either epidermal growth factor or heparin-binding growth factor/prostatropin...

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Bibliographic Details
Published in:In Vitro Cellular & Developmental Biology 1988-03, Vol.24 (3), p.243-246
Main Authors: MCKEEHAN, W. L, ADAMS, P. S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Count
Cell Division - drug effects
Cell growth
Cell physiology
Endothelial cells
Epithelial cells
Epithelium - pathology
Fibroblast Growth Factor 2
Fibroblast growth factors
Fundamental and applied biological sciences. Psychology
Growth Substances - pharmacology
Heparin - pharmacology
Hepatocytes
Insulin
Male
Mitogens
Molecular and cellular biology
Nerve Tissue Proteins - pharmacology
Peptides - pharmacology
Prostate
Prostate cancer
Prostatic Neoplasms - pathology
Rapid Communications in Cell Biology
Rats
Responses to growth factors, tumor promotors, other factors
Transforming Growth Factors
Tumor Cells, Cultured
Tumors
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Summary:Normal rat prostate epithelial cell growth requires both epidermal growth factor and heparin-binding growth factor/prostatropin. In contrast, epithelial cells derived from the transplantable Dunning R3327H rat tumor require either epidermal growth factor or heparin-binding growth factor/prostatropin. Transforming growth factor type beta inhibited normal epithelial cell growth. Transforming growth factor beta inhibited epidermal growth factor-dependent growth of tumor epithelial cells, independent of epidermal growth factor concentrations. Transforming growth factor beta increased the effective dose of heparin-binding growth factor type 1 required to support tumor epithelial cell growth by 10-fold but saturating levels of heparin-binding growth factor type 1 (290 pM) completely attenuated the inhibitory effect of transforming growth factor beta. These results suggest that prostate tumor epithelial cells may escape the inhibitory effect of transforming growth factor beta as a consequence of alteration of the concurrent requirement for both epidermal growth factor (or homologues) and heparin-binding growth factors.
ISSN:0883-8364
2327-431X
1475-2689
DOI:10.1007/BF02623554