Extra Y chromosome in T-cell acute lymphoblastic leukemia

We describe a 66-year-old man who developed T-cell acute lymphoblastic leukemia (ALL) with a sole clonal chromosomal abnormality of 47,XY,+Y. Leukemic cells were positive for CD2, CD7, terminal deoxynucleotidyl transferase and cytoplasmic CD3. T-cell receptor β, γ, and δ genes remained germline conf...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1996-07, Vol.89 (1), p.85-87
Main Authors: Watanabe, Ayako, Kawachi, Yasunori, Nishihara, Toshio, Uchida, Tatsumi, Setsu, Kojun, Hikiji, Kazumasa
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chromosome Aberrations
Genes, fos
Hematologic and hematopoietic diseases
Humans
Leukemia-Lymphoma, Adult T-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Y Chromosome
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Summary:We describe a 66-year-old man who developed T-cell acute lymphoblastic leukemia (ALL) with a sole clonal chromosomal abnormality of 47,XY,+Y. Leukemic cells were positive for CD2, CD7, terminal deoxynucleotidyl transferase and cytoplasmic CD3. T-cell receptor β, γ, and δ genes remained germline configurations. The bone marrow aspirate was 47,XY,+Y in all metaphase cells observed. The patient achieved complete remission by chemotherapy, and the bone marrow cells and the phytohemagglutinin stimulated peripheral blood lymphocytes showed a normal karyotype of 46,XY at that time. This fact suggests that an extra Y chromosome may be a kind of new chromosomal abnormality of T-cell ALL.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(95)00351-7