Fluorescence photography in the evaluation of acne

Background: Quantification of acne remains a challenge. It may be difficult to identify lesions by standard flash photography. Previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin IX production by Propionibacterium acnes in open comedones, foll...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1996-07, Vol.35 (1), p.58-63
Main Authors: Lucchina, Leslie C., Kollias, Nikiforos, Gillies, Robert, Phillips, Scott B., Muccini, Joseph A., Stiller, Matthew J., Trancik, Ronald J., Drake, Lynn A.
Format: Article
Language:English
Subjects:
Acne Vulgaris - drug therapy
Acne Vulgaris - metabolism
Acne Vulgaris - pathology
Administration, Cutaneous
Adolescent
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Clindamycin - administration & dosage
Clindamycin - analogs & derivatives
Clindamycin - therapeutic use
Dermatology
Double-Blind Method
Facial Dermatoses - drug therapy
Facial Dermatoses - metabolism
Facial Dermatoses - pathology
Female
Fluorescence
Follow-Up Studies
Hair Follicle - metabolism
Humans
Male
Medical sciences
Pharmaceutical Vehicles
Photography - methods
Propionibacterium acnes - metabolism
Protoporphyrins - metabolism
Skin involvement in other diseases. Miscellaneous. General aspects
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Summary:Background: Quantification of acne remains a challenge. It may be difficult to identify lesions by standard flash photography. Previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin IX production by Propionibacterium acnes in open comedones, follicles, and inflammatory lesions. Objective: Our purpose was to study the utility of fluorescence photography for evaluation of acne. Methods: Forty subjects with mild to moderate acne vulgaris were randomly selected to apply either clindamycin 1% topical solution or vehicle twice daily. Counts of acne lesions and flash and fluorescence photographs were obtained at baseline, and at 4, 8, and 12 weeks. Results: At 12 weeks, the treatment group had a larger percentage change in open comedones, less fluorescence in all areas assessed, and a larger percent decrease in fluorescence than the vehicle group. Conclusion: Fluorescence photography appears to be a useful tool to chart the course of acne treatment.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(96)90497-1