Identification of brain lesions in neuropsychiatric systemic lupus erythematosus by magnetic resonance scanning

Cranial magnetic resonance imaging in 28 systemic lupus erythematosus patients who had experienced 30 acute neuropsychiatric events showed focal brain lesions in 16 of 30 events (53%) and low brain volume (atrophy) in 20 of 30 events (67%). Definite focal lesions were significantly more frequent in...

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Bibliographic Details
Published in:Arthritis and rheumatism 1988-02, Vol.31 (2), p.159-166
Main Authors: Mccune, W. Joseph, Macguire, Anne, Aisen, Alex, Gebarski, Stephen
Format: Article
Language:English
Subjects:
Adult
Atrophy
Biological and medical sciences
Brain - pathology
Brain Diseases - diagnosis
Brain Diseases - diagnostic imaging
Brain Diseases - pathology
Female
Humans
Lupus Erythematosus, Systemic - complications
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Psychotic Disorders - etiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Seizures - etiology
Tomography, X-Ray Computed
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Summary:Cranial magnetic resonance imaging in 28 systemic lupus erythematosus patients who had experienced 30 acute neuropsychiatric events showed focal brain lesions in 16 of 30 events (53%) and low brain volume (atrophy) in 20 of 30 events (67%). Definite focal lesions were significantly more frequent in patients with clinically localized neurologic deficits (8 of 8, 100%), or seizures (5 of 6, 83%) than in patients without such localizing signs (3 of 16, 19%). Many of these lesions were occult on intravenous contrast‐enhanced x‐ray computed tomography. In 2 patients, lesions in gray matter resolved within 2 or 3 weeks, in association with clinical improvement. Magnetic resonance imaging is an important technique for detecting the extent of brain injury in cerebral lupus.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780310202