Forced vital capacity and the risk of hypertension. The normative aging study

This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Norma...

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Bibliographic Details
Published in:American journal of epidemiology 1988-04, Vol.127 (4), p.734-741
Main Authors: SPARROW, D, WEISS, S. T, VOKONAS, P. S, CUPPLES, L. A, EKERDT, D. J, COLTON, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Body Height
Body Weight
Cardiology. Vascular system
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Humans
Hypertension - epidemiology
Medical sciences
Middle Aged
Prognosis
Prospective Studies
Residual Volume
Risk
Vital Capacity
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Summary:This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a longitudinal study on aging initiated in 1961 at the Veterans Administration Outpatient Clinic in Boston, Massachusetts. Blood pressures were taken at five- and 10-year follow-up examinations. The age-adjusted incidence of hypertension during the follow-up period was found to be inversely related to forced vital capacity. Multiple logistic regression was employed to assess the relation of forced vital capacity to the subsequent development of hypertension after controlling for baseline levels of age, weight, cigarettes smoked per day, and systolic and diastolic blood pressures. Forced vital capacity was a statistically significant and negative predictor, indicating that lower values of forced vital capacity were associated with the subsequent development of hypertension. This was consistently found in several logistic regression analyses with a standardized odds ratio associated with forced vital capacity of approximately 0.7. Although the physiologic mechanism for this association is unknown, these findings may have importance in identifying subjects at risk and may also provide insight into disease pathogenesis.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a114854