Interaction of RGD Liposomes with Platelets

The interactions of platelets and liposomes with the tripeptide arginine-glycine-aspartic acid (RGD) as a surface ligand (RGD liposomes) were studied. The results suggest that the presence of the RGD ligand on the liposomes results in receptor-mediated mixing of lipid and aqueous contents of the lip...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-07, Vol.224 (1), p.242-245
Main Authors: Nishiya, Takako, Sloan, Stephen
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - drug effects
Blood Platelets - physiology
Calcium - blood
Cattle
Dimyristoylphosphatidylcholine
Drug Carriers
Fluorescent Dyes
Fura-2
In Vitro Techniques
Kinetics
Liposomes
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Phosphatidylglycerols
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Summary:The interactions of platelets and liposomes with the tripeptide arginine-glycine-aspartic acid (RGD) as a surface ligand (RGD liposomes) were studied. The results suggest that the presence of the RGD ligand on the liposomes results in receptor-mediated mixing of lipid and aqueous contents of the liposomes and platelets. Mixing of the lipid and aqueous contents of RGD liposomes with platelets is approximately 4–9 times and 3–4 times greater than that for unlabeled liposomes, respectively. Measurements of the cytoplasmic free Ca2+concentration in platelets, [Ca2+]i, show that the RGD liposomes have little effect on [Ca2+]i.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.1014