Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety

The behavioral effects of intracerebroventricular (ICV) administration of a specific mineralocorticoid receptor (MR) antagonist [RU28318 (10–50 ng/2 μl)], a glucocorticoid receptor (GR) antagonist [RU38486 (1–50 ng/2 μl)], or both antagonists (50 ng/2 μl), were studied in two different animal models...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-05, Vol.54 (1), p.261-267
Main Authors: Korte, S.Mechiel, Korte-Bouws, Gerdien A.H., Koob, George F., De Kloet, E.Ronald, Bohus, Béla
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adult and adolescent clinical studies
Animals
Anxiety
Anxiety - psychology
Anxiety disorders. Neuroses
Behavior, Animal - drug effects
Biological and medical sciences
Defensive burying
Electroshock
Fear
Fear - drug effects
Fear-potentiated startle
Glucocorticoid receptor
Hormone Antagonists - pharmacology
Injections, Intraventricular
Male
Medical sciences
Mifepristone - pharmacology
Mineralocorticoid receptor
Mineralocorticoid Receptor Antagonists - pharmacology
Miscellaneous
Motor Activity - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Wistar
Receptors, Glucocorticoid - antagonists & inhibitors
Reflex, Startle - drug effects
Spironolactone - analogs & derivatives
Spironolactone - pharmacology
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Summary:The behavioral effects of intracerebroventricular (ICV) administration of a specific mineralocorticoid receptor (MR) antagonist [RU28318 (10–50 ng/2 μl)], a glucocorticoid receptor (GR) antagonist [RU38486 (1–50 ng/2 μl)], or both antagonists (50 ng/2 μl), were studied in two different animal models of fear and anxiety in rats. In the defensive burying paradigm simultaneous blockade of MR and GR increased immobility behavior, whereas a small decrease in defensive burying was seen. In the fear-potentiated startle test concurrent MR and GR blockade led to an increase in fear-potentiated startle at the highest loudness level (105 dB). In both tests the antagonists were not effective when given separately. The findings are discussed in terms of the involvement of GR and MR in neural mechanisms of fear and anxiety.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(95)02172-8