Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a rationale for the molecular causes of cancer and a therapy

In the human, coenzyme Q10 (vitamin Q10) is biosynthesized from tyrosine through a cascade of eight aromatic precursors. These precursors indispensably require eight vitamins, which are tetrahydrobiopterin, vitamins B6, C, B2, B12, folic acid, niacin, and pantothenic acid as their coenzymes. Three o...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-07, Vol.224 (2), p.358-361
Main Author: Folkers, K
Format: Article
Language:English
Subjects:
Breast Neoplasms - epidemiology
Coenzymes
DNA - biosynthesis
DNA - chemistry
Female
Humans
Incidence
Neoplasms - blood
Neoplasms - etiology
Neoplasms - therapy
Purines - biosynthesis
Pyrimidines - biosynthesis
Reference Values
Sweden - epidemiology
Ubiquinone - analogs & derivatives
Ubiquinone - biosynthesis
Ubiquinone - blood
Ubiquinone - metabolism
Vitamins
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Summary:In the human, coenzyme Q10 (vitamin Q10) is biosynthesized from tyrosine through a cascade of eight aromatic precursors. These precursors indispensably require eight vitamins, which are tetrahydrobiopterin, vitamins B6, C, B2, B12, folic acid, niacin, and pantothenic acid as their coenzymes. Three of these eight vitamins (the coenzyme B6, and the coenzymes niacin and folic acid) are indispensable in the biosynthesis of the four bases (thymidine, guanine, adenine, and cytosine) of DNA. One or more of the three vitamins required for DNA are known to cause abnormal pairing of the four bases, which can then result in mutations and the diversity of cancer. The coenzyme B6, required for the conversion of tyrosine to p-hydroxybenzoic acid, is the first coenzyme required in the cascade of precursors. A deficiency of the coenzyme B6 can cause dysfunctions, prior to the formation of vitamin Q10, to DNA. Former data on blood levels of Q10 and new data herein on blood levels of B6, measured as EDTA, in cancer patients established deficiencies of Q10 and B6 in cancer. This complete biochemistry relating to biosyntheses of Q10 and the DNA bases is a rationale for the therapy of cancer with Q10 and other entities in this biochemistry.
ISSN:0006-291X
DOI:10.1006/bbrc.1996.1033