Loading…
Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis
Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 U.S.A., 1 Institute of Poliomyelitis and Viral Encephalitides, Moscow, U.S.S.R. 2 Global EIS Program, Mexico Center for Prevention Services, Centers for Disease Control, Atlanta, Georgia 3...
Saved in:
| Published in: | Journal of general virology 1988-03, Vol.69 (3), p.731-738 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4151-5aba0f34c7cafd7f527826849f2d8578800eb19a6dc411e7007f1091e6d481fb3 |
|---|---|
| cites | |
| container_end_page | 738 |
| container_issue | 3 |
| container_start_page | 731 |
| container_title | Journal of general virology |
| container_volume | 69 |
| creator | Bradley, Daniel Andjaparidze, Alexander Cook, E. H., Jr McCaustland, Karen Balayan, Mikhail Stetler, Harrison Velazquez, Oscar Robertson, Betty Humphrey, Charles Kane, Mark Weisfuse, Isaac |
| description | Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 U.S.A.,
1 Institute of Poliomyelitis and Viral Encephalitides, Moscow, U.S.S.R.
2 Global EIS Program, Mexico Center for Prevention Services, Centers for Disease Control, Atlanta, Georgia 30333, U.S.A.
and 3 Global EIS Program, Ministry of Health, Mexico City, Mexico
Virus-like particles (VLPs) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-A, non-B hepatitis (ET-NANBH) occurring in the Soviet Union, North Africa and North America. VLPs from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of ET-NANBH in Asia, the Soviet Union, North Africa and North America. Partially purified VLPs were found to sediment at 183S in sucrose gradients and to cross-react with antibody in acute phase sera from geographically isolated cases of ET-NANBH. The latter virus preparations were also used to document the seroconversion of experimentally ET-NANBH-infected cynomolgus macaques to 32 nm VLPs. Our findings indicate that one virus or class of viruses is responsible for the majority of ET-NANBH.
Keywords: hepatitis, non-A, non-B, enteric transmission, aetiological agent
Received 23 July 1987;
accepted 4 December 1987. |
| doi_str_mv | 10.1099/0022-1317-69-3-731 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78158893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78158893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4151-5aba0f34c7cafd7f527826849f2d8578800eb19a6dc411e7007f1091e6d481fb3</originalsourceid><addsrcrecordid>eNqFkE1PAyEQhonRaP34AyYmezB6EWWABfZYtX4kRi_1TNhdqJj9qLDV9N9LbdOrp0nmfWYGHoROgVwDKYobQijFwEBiUWCGJYMdNAIuckxTvItGW-AAHcb4SQhwnst9tM-AypyzEbof28H3TT_zlWmy8cx2Q9a7bNINNqxazTKbBtPF1g-DrbPXvsPjq79ymz3ZuRn84OMx2nOmifZkU4_Q-8NkeveEX94en-_GL7jikAPOTWmIY7ySlXG1dDmVigrFC0drlUulCLElFEbUiQcrCZEu_ROsqLkCV7IjdLHeOw_918LGQbc-VrZpTGf7RdRSQa5Uwf4FgSspmKAJpGuwCn2MwTo9D741YamB6JVjvVKoVwq1KDTTyXEaOttsX5StrbcjG6kpP9_kJiaFLvmrfNxiUoAUXCTsco19-NnHjw9WJ_utTy8pfa-_fdge_AX7149V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14876362</pqid></control><display><type>article</type><title>Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis</title><source>Freely Accessible Journals</source><creator>Bradley, Daniel ; Andjaparidze, Alexander ; Cook, E. H., Jr ; McCaustland, Karen ; Balayan, Mikhail ; Stetler, Harrison ; Velazquez, Oscar ; Robertson, Betty ; Humphrey, Charles ; Kane, Mark ; Weisfuse, Isaac</creator><creatorcontrib>Bradley, Daniel ; Andjaparidze, Alexander ; Cook, E. H., Jr ; McCaustland, Karen ; Balayan, Mikhail ; Stetler, Harrison ; Velazquez, Oscar ; Robertson, Betty ; Humphrey, Charles ; Kane, Mark ; Weisfuse, Isaac</creatorcontrib><description>Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 U.S.A.,
1 Institute of Poliomyelitis and Viral Encephalitides, Moscow, U.S.S.R.
2 Global EIS Program, Mexico Center for Prevention Services, Centers for Disease Control, Atlanta, Georgia 30333, U.S.A.
and 3 Global EIS Program, Ministry of Health, Mexico City, Mexico
Virus-like particles (VLPs) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-A, non-B hepatitis (ET-NANBH) occurring in the Soviet Union, North Africa and North America. VLPs from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of ET-NANBH in Asia, the Soviet Union, North Africa and North America. Partially purified VLPs were found to sediment at 183S in sucrose gradients and to cross-react with antibody in acute phase sera from geographically isolated cases of ET-NANBH. The latter virus preparations were also used to document the seroconversion of experimentally ET-NANBH-infected cynomolgus macaques to 32 nm VLPs. Our findings indicate that one virus or class of viruses is responsible for the majority of ET-NANBH.
Keywords: hepatitis, non-A, non-B, enteric transmission, aetiological agent
Received 23 July 1987;
accepted 4 December 1987.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-69-3-731</identifier><identifier>PMID: 3127543</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Animals ; Antibodies, Viral - analysis ; Biological and medical sciences ; Cross Reactions ; Feces - microbiology ; Hepatitis C - microbiology ; Hepatitis C - transmission ; hepatitis D virus ; Hepatitis Viruses - classification ; Hepatitis Viruses - immunology ; Hepatitis Viruses - isolation & purification ; Hepatitis Viruses - ultrastructure ; Hepatitis, Viral, Human - microbiology ; Human viral diseases ; Humans ; Infectious diseases ; Macaca fascicularis ; Medical sciences ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of general virology, 1988-03, Vol.69 (3), p.731-738</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-5aba0f34c7cafd7f527826849f2d8578800eb19a6dc411e7007f1091e6d481fb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7617646$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3127543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bradley, Daniel</creatorcontrib><creatorcontrib>Andjaparidze, Alexander</creatorcontrib><creatorcontrib>Cook, E. H., Jr</creatorcontrib><creatorcontrib>McCaustland, Karen</creatorcontrib><creatorcontrib>Balayan, Mikhail</creatorcontrib><creatorcontrib>Stetler, Harrison</creatorcontrib><creatorcontrib>Velazquez, Oscar</creatorcontrib><creatorcontrib>Robertson, Betty</creatorcontrib><creatorcontrib>Humphrey, Charles</creatorcontrib><creatorcontrib>Kane, Mark</creatorcontrib><creatorcontrib>Weisfuse, Isaac</creatorcontrib><title>Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 U.S.A.,
1 Institute of Poliomyelitis and Viral Encephalitides, Moscow, U.S.S.R.
2 Global EIS Program, Mexico Center for Prevention Services, Centers for Disease Control, Atlanta, Georgia 30333, U.S.A.
and 3 Global EIS Program, Ministry of Health, Mexico City, Mexico
Virus-like particles (VLPs) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-A, non-B hepatitis (ET-NANBH) occurring in the Soviet Union, North Africa and North America. VLPs from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of ET-NANBH in Asia, the Soviet Union, North Africa and North America. Partially purified VLPs were found to sediment at 183S in sucrose gradients and to cross-react with antibody in acute phase sera from geographically isolated cases of ET-NANBH. The latter virus preparations were also used to document the seroconversion of experimentally ET-NANBH-infected cynomolgus macaques to 32 nm VLPs. Our findings indicate that one virus or class of viruses is responsible for the majority of ET-NANBH.
Keywords: hepatitis, non-A, non-B, enteric transmission, aetiological agent
Received 23 July 1987;
accepted 4 December 1987.</description><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>Feces - microbiology</subject><subject>Hepatitis C - microbiology</subject><subject>Hepatitis C - transmission</subject><subject>hepatitis D virus</subject><subject>Hepatitis Viruses - classification</subject><subject>Hepatitis Viruses - immunology</subject><subject>Hepatitis Viruses - isolation & purification</subject><subject>Hepatitis Viruses - ultrastructure</subject><subject>Hepatitis, Viral, Human - microbiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Macaca fascicularis</subject><subject>Medical sciences</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNqFkE1PAyEQhonRaP34AyYmezB6EWWABfZYtX4kRi_1TNhdqJj9qLDV9N9LbdOrp0nmfWYGHoROgVwDKYobQijFwEBiUWCGJYMdNAIuckxTvItGW-AAHcb4SQhwnst9tM-AypyzEbof28H3TT_zlWmy8cx2Q9a7bNINNqxazTKbBtPF1g-DrbPXvsPjq79ymz3ZuRn84OMx2nOmifZkU4_Q-8NkeveEX94en-_GL7jikAPOTWmIY7ySlXG1dDmVigrFC0drlUulCLElFEbUiQcrCZEu_ROsqLkCV7IjdLHeOw_918LGQbc-VrZpTGf7RdRSQa5Uwf4FgSspmKAJpGuwCn2MwTo9D741YamB6JVjvVKoVwq1KDTTyXEaOttsX5StrbcjG6kpP9_kJiaFLvmrfNxiUoAUXCTsco19-NnHjw9WJ_utTy8pfa-_fdge_AX7149V</recordid><startdate>198803</startdate><enddate>198803</enddate><creator>Bradley, Daniel</creator><creator>Andjaparidze, Alexander</creator><creator>Cook, E. H., Jr</creator><creator>McCaustland, Karen</creator><creator>Balayan, Mikhail</creator><creator>Stetler, Harrison</creator><creator>Velazquez, Oscar</creator><creator>Robertson, Betty</creator><creator>Humphrey, Charles</creator><creator>Kane, Mark</creator><creator>Weisfuse, Isaac</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198803</creationdate><title>Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis</title><author>Bradley, Daniel ; Andjaparidze, Alexander ; Cook, E. H., Jr ; McCaustland, Karen ; Balayan, Mikhail ; Stetler, Harrison ; Velazquez, Oscar ; Robertson, Betty ; Humphrey, Charles ; Kane, Mark ; Weisfuse, Isaac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4151-5aba0f34c7cafd7f527826849f2d8578800eb19a6dc411e7007f1091e6d481fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>Feces - microbiology</topic><topic>Hepatitis C - microbiology</topic><topic>Hepatitis C - transmission</topic><topic>hepatitis D virus</topic><topic>Hepatitis Viruses - classification</topic><topic>Hepatitis Viruses - immunology</topic><topic>Hepatitis Viruses - isolation & purification</topic><topic>Hepatitis Viruses - ultrastructure</topic><topic>Hepatitis, Viral, Human - microbiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Macaca fascicularis</topic><topic>Medical sciences</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bradley, Daniel</creatorcontrib><creatorcontrib>Andjaparidze, Alexander</creatorcontrib><creatorcontrib>Cook, E. H., Jr</creatorcontrib><creatorcontrib>McCaustland, Karen</creatorcontrib><creatorcontrib>Balayan, Mikhail</creatorcontrib><creatorcontrib>Stetler, Harrison</creatorcontrib><creatorcontrib>Velazquez, Oscar</creatorcontrib><creatorcontrib>Robertson, Betty</creatorcontrib><creatorcontrib>Humphrey, Charles</creatorcontrib><creatorcontrib>Kane, Mark</creatorcontrib><creatorcontrib>Weisfuse, Isaac</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bradley, Daniel</au><au>Andjaparidze, Alexander</au><au>Cook, E. H., Jr</au><au>McCaustland, Karen</au><au>Balayan, Mikhail</au><au>Stetler, Harrison</au><au>Velazquez, Oscar</au><au>Robertson, Betty</au><au>Humphrey, Charles</au><au>Kane, Mark</au><au>Weisfuse, Isaac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1988-03</date><risdate>1988</risdate><volume>69</volume><issue>3</issue><spage>731</spage><epage>738</epage><pages>731-738</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 U.S.A.,
1 Institute of Poliomyelitis and Viral Encephalitides, Moscow, U.S.S.R.
2 Global EIS Program, Mexico Center for Prevention Services, Centers for Disease Control, Atlanta, Georgia 30333, U.S.A.
and 3 Global EIS Program, Ministry of Health, Mexico City, Mexico
Virus-like particles (VLPs) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-A, non-B hepatitis (ET-NANBH) occurring in the Soviet Union, North Africa and North America. VLPs from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of ET-NANBH in Asia, the Soviet Union, North Africa and North America. Partially purified VLPs were found to sediment at 183S in sucrose gradients and to cross-react with antibody in acute phase sera from geographically isolated cases of ET-NANBH. The latter virus preparations were also used to document the seroconversion of experimentally ET-NANBH-infected cynomolgus macaques to 32 nm VLPs. Our findings indicate that one virus or class of viruses is responsible for the majority of ET-NANBH.
Keywords: hepatitis, non-A, non-B, enteric transmission, aetiological agent
Received 23 July 1987;
accepted 4 December 1987.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>3127543</pmid><doi>10.1099/0022-1317-69-3-731</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1317 |
| ispartof | Journal of general virology, 1988-03, Vol.69 (3), p.731-738 |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78158893 |
| source | Freely Accessible Journals |
| subjects | Animals Antibodies, Viral - analysis Biological and medical sciences Cross Reactions Feces - microbiology Hepatitis C - microbiology Hepatitis C - transmission hepatitis D virus Hepatitis Viruses - classification Hepatitis Viruses - immunology Hepatitis Viruses - isolation & purification Hepatitis Viruses - ultrastructure Hepatitis, Viral, Human - microbiology Human viral diseases Humans Infectious diseases Macaca fascicularis Medical sciences Viral diseases Viral hepatitis |
| title | Aetiological Agent of Enterically Transmitted Non-A, Non-B Hepatitis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T23%3A37%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aetiological%20Agent%20of%20Enterically%20Transmitted%20Non-A,%20Non-B%20Hepatitis&rft.jtitle=Journal%20of%20general%20virology&rft.au=Bradley,%20Daniel&rft.date=1988-03&rft.volume=69&rft.issue=3&rft.spage=731&rft.epage=738&rft.pages=731-738&rft.issn=0022-1317&rft.eissn=1465-2099&rft.coden=JGVIAY&rft_id=info:doi/10.1099/0022-1317-69-3-731&rft_dat=%3Cproquest_cross%3E78158893%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4151-5aba0f34c7cafd7f527826849f2d8578800eb19a6dc411e7007f1091e6d481fb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=14876362&rft_id=info:pmid/3127543&rfr_iscdi=true |