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Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons
The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two an...
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Published in: | Vision research (Oxford) 1996-03, Vol.36 (6), p.775-786 |
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description | The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two antigens were similarly distributed in the pigeon choroid, with the superior and temporal quadrants of the eye containing the most fibers. Both types of fibers surrounded and ramified on choroidal blood vessels. Additionally, CHAT+ varicosities were evident among vessels in the choroid and choriocapillaris. Double-label immunofluorescence revealed that CHAT and the 3A10 antigen were almost completely colocalized in choroidal nerve fibers, but absent from CHAT+ varicosities. Substance P-containing and calcitonin gene-related peptide-containing choroidal nerve fibers were poor in 3A10+ labeling. Transection of the postganglionic fibers of the CG reduced CHAT+ and 3A10+ nerve fibers in the choroid to 3–5% of normal abundance, with most of the residual fibers being located in the nasal and inferior quadrants. The present results suggest that the CG in pigeon preferentially influences choroidal blood flow in the superior and temporal parts of the eye, which are involved in high acuity and binocular vision. |
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Single-labeling revealed that the nerve fibers containing these two antigens were similarly distributed in the pigeon choroid, with the superior and temporal quadrants of the eye containing the most fibers. Both types of fibers surrounded and ramified on choroidal blood vessels. Additionally, CHAT+ varicosities were evident among vessels in the choroid and choriocapillaris. Double-label immunofluorescence revealed that CHAT and the 3A10 antigen were almost completely colocalized in choroidal nerve fibers, but absent from CHAT+ varicosities. Substance P-containing and calcitonin gene-related peptide-containing choroidal nerve fibers were poor in 3A10+ labeling. Transection of the postganglionic fibers of the CG reduced CHAT+ and 3A10+ nerve fibers in the choroid to 3–5% of normal abundance, with most of the residual fibers being located in the nasal and inferior quadrants. The present results suggest that the CG in pigeon preferentially influences choroidal blood flow in the superior and temporal parts of the eye, which are involved in high acuity and binocular vision.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/0042-6989(95)00179-4</identifier><identifier>PMID: 8736214</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibodies, Monoclonal ; Autonomic innervation ; Aves ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - immunology ; Choline O-Acetyltransferase - immunology ; Cholinergic Fibers - ultrastructure ; Choroid ; Choroid - blood supply ; Choroid - innervation ; Choroidal blood flow ; Ciliary Body - innervation ; Columbidae - anatomy & histology ; Eye and associated structures. Visual pathways and centers. Vision ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Immune Sera ; Immunoenzyme Techniques ; Immunohistochemistry ; Pigeons ; Regional Blood Flow ; Substance P - immunology ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 1996-03, Vol.36 (6), p.775-786</ispartof><rights>1996 Elsevier Science Ltd</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-246593e9c81e855418bf8ad5b1e74ed4cda41fda003175b6f30b8b89588c8b893</citedby><cites>FETCH-LOGICAL-c463t-246593e9c81e855418bf8ad5b1e74ed4cda41fda003175b6f30b8b89588c8b893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2999880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8736214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cuthbertson, Sherry</creatorcontrib><creatorcontrib>White, Jennifer</creatorcontrib><creatorcontrib>Fitzgerald, Malinda E.C.</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><creatorcontrib>Reiner, Anton</creatorcontrib><title>Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two antigens were similarly distributed in the pigeon choroid, with the superior and temporal quadrants of the eye containing the most fibers. Both types of fibers surrounded and ramified on choroidal blood vessels. Additionally, CHAT+ varicosities were evident among vessels in the choroid and choriocapillaris. Double-label immunofluorescence revealed that CHAT and the 3A10 antigen were almost completely colocalized in choroidal nerve fibers, but absent from CHAT+ varicosities. Substance P-containing and calcitonin gene-related peptide-containing choroidal nerve fibers were poor in 3A10+ labeling. Transection of the postganglionic fibers of the CG reduced CHAT+ and 3A10+ nerve fibers in the choroid to 3–5% of normal abundance, with most of the residual fibers being located in the nasal and inferior quadrants. The present results suggest that the CG in pigeon preferentially influences choroidal blood flow in the superior and temporal parts of the eye, which are involved in high acuity and binocular vision.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Autonomic innervation</subject><subject>Aves</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - immunology</subject><subject>Choline O-Acetyltransferase - immunology</subject><subject>Cholinergic Fibers - ultrastructure</subject><subject>Choroid</subject><subject>Choroid - blood supply</subject><subject>Choroid - innervation</subject><subject>Choroidal blood flow</subject><subject>Ciliary Body - innervation</subject><subject>Columbidae - anatomy & histology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immune Sera</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>Pigeons</subject><subject>Regional Blood Flow</subject><subject>Substance P - immunology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkUFP3DAQha0KBMvSf9BKOaCKHgJ2Yjv2BamCtiCt1AucXccZ7w7Kxls7C-Lf1-mu9lhOb6T55o39hpBPjF4xyuQ1pbwqpVb6UouvlLJGl_wDmTHVqFJILo_I7ICckrOUnimljaj0CTlRTS0rxmfk9x2mMWK7HTEMxSuOKxyKcQWFW4UYsCuCn8oeB4hLdEWWFyg8thBT4WNY72Ds0ca3YmmHZT8ZZZMNLiEM6Zwce9sn-LjXOXn68f3x9r5c_Pr5cPttUTou67GsuBS6Bu0UAyUEZ6r1ynaiZdBw6LjrLGe-s5TWrBGt9DVtVau0UMpNWs_Jl53vJoY_W0ijWWNy0Pd2gLBNplFM8lrJd0EmGinymgzyHehiSCmCN5uI6_xNw6iZLmCmeM0Ur9HC_LuA4Xns895_266hOwztI8_9i33fJmd7H-3gMB2wSmutFM3YzQ6DHNoLQjTJIQwOOozgRtMF_P87_gJjqaJ3</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Cuthbertson, Sherry</creator><creator>White, Jennifer</creator><creator>Fitzgerald, Malinda E.C.</creator><creator>Shih, Yung-Feng</creator><creator>Reiner, Anton</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons</title><author>Cuthbertson, Sherry ; White, Jennifer ; Fitzgerald, Malinda E.C. ; Shih, Yung-Feng ; Reiner, Anton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-246593e9c81e855418bf8ad5b1e74ed4cda41fda003175b6f30b8b89588c8b893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Autonomic innervation</topic><topic>Aves</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - immunology</topic><topic>Choline O-Acetyltransferase - immunology</topic><topic>Cholinergic Fibers - ultrastructure</topic><topic>Choroid</topic><topic>Choroid - blood supply</topic><topic>Choroid - innervation</topic><topic>Choroidal blood flow</topic><topic>Ciliary Body - innervation</topic><topic>Columbidae - anatomy & histology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immune Sera</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>Pigeons</topic><topic>Regional Blood Flow</topic><topic>Substance P - immunology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuthbertson, Sherry</creatorcontrib><creatorcontrib>White, Jennifer</creatorcontrib><creatorcontrib>Fitzgerald, Malinda E.C.</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><creatorcontrib>Reiner, Anton</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuthbertson, Sherry</au><au>White, Jennifer</au><au>Fitzgerald, Malinda E.C.</au><au>Shih, Yung-Feng</au><au>Reiner, Anton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>36</volume><issue>6</issue><spage>775</spage><epage>786</epage><pages>775-786</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two antigens were similarly distributed in the pigeon choroid, with the superior and temporal quadrants of the eye containing the most fibers. Both types of fibers surrounded and ramified on choroidal blood vessels. Additionally, CHAT+ varicosities were evident among vessels in the choroid and choriocapillaris. Double-label immunofluorescence revealed that CHAT and the 3A10 antigen were almost completely colocalized in choroidal nerve fibers, but absent from CHAT+ varicosities. Substance P-containing and calcitonin gene-related peptide-containing choroidal nerve fibers were poor in 3A10+ labeling. Transection of the postganglionic fibers of the CG reduced CHAT+ and 3A10+ nerve fibers in the choroid to 3–5% of normal abundance, with most of the residual fibers being located in the nasal and inferior quadrants. The present results suggest that the CG in pigeon preferentially influences choroidal blood flow in the superior and temporal parts of the eye, which are involved in high acuity and binocular vision.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8736214</pmid><doi>10.1016/0042-6989(95)00179-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antibodies, Monoclonal Autonomic innervation Aves Biological and medical sciences Calcitonin Gene-Related Peptide - immunology Choline O-Acetyltransferase - immunology Cholinergic Fibers - ultrastructure Choroid Choroid - blood supply Choroid - innervation Choroidal blood flow Ciliary Body - innervation Columbidae - anatomy & histology Eye and associated structures. Visual pathways and centers. Vision Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Immune Sera Immunoenzyme Techniques Immunohistochemistry Pigeons Regional Blood Flow Substance P - immunology Vertebrates: nervous system and sense organs |
title | Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons |
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