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Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons

The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two an...

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Published in:Vision research (Oxford) 1996-03, Vol.36 (6), p.775-786
Main Authors: Cuthbertson, Sherry, White, Jennifer, Fitzgerald, Malinda E.C., Shih, Yung-Feng, Reiner, Anton
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description The distribution of the ciliary ganglion (CG) innervation to the pigeon choroid was determined immunohistochemically, using antisera against choline acetyltransferase (CHAT) and a neurofilament-related protein (the 3A10 antigen). Single-labeling revealed that the nerve fibers containing these two antigens were similarly distributed in the pigeon choroid, with the superior and temporal quadrants of the eye containing the most fibers. Both types of fibers surrounded and ramified on choroidal blood vessels. Additionally, CHAT+ varicosities were evident among vessels in the choroid and choriocapillaris. Double-label immunofluorescence revealed that CHAT and the 3A10 antigen were almost completely colocalized in choroidal nerve fibers, but absent from CHAT+ varicosities. Substance P-containing and calcitonin gene-related peptide-containing choroidal nerve fibers were poor in 3A10+ labeling. Transection of the postganglionic fibers of the CG reduced CHAT+ and 3A10+ nerve fibers in the choroid to 3–5% of normal abundance, with most of the residual fibers being located in the nasal and inferior quadrants. The present results suggest that the CG in pigeon preferentially influences choroidal blood flow in the superior and temporal parts of the eye, which are involved in high acuity and binocular vision.
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identifier ISSN: 0042-6989
ispartof Vision research (Oxford), 1996-03, Vol.36 (6), p.775-786
issn 0042-6989
1878-5646
language eng
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subjects Animals
Antibodies, Monoclonal
Autonomic innervation
Aves
Biological and medical sciences
Calcitonin Gene-Related Peptide - immunology
Choline O-Acetyltransferase - immunology
Cholinergic Fibers - ultrastructure
Choroid
Choroid - blood supply
Choroid - innervation
Choroidal blood flow
Ciliary Body - innervation
Columbidae - anatomy & histology
Eye and associated structures. Visual pathways and centers. Vision
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Immune Sera
Immunoenzyme Techniques
Immunohistochemistry
Pigeons
Regional Blood Flow
Substance P - immunology
Vertebrates: nervous system and sense organs
title Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons
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