Value of lymph node biopsy in the diagnosis of acquired toxoplasmosis

Toxoplasmic lymphadenitis generally involves a solitary lymph node in the head and neck regions, without systemic symptoms. In order to determine the frequency of toxoplasmic lymphadenitis, we reviewed the histological sections of 731 consecutive patients with reactive lymph node hyperplasia. Amongs...

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Bibliographic Details
Published in:Journal of laryngology and otology 1996-04, Vol.110 (4), p.348-352
Main Authors: Tuzuner, Nukhet, Doǧusoy, Gülen, Demirkesen, Cuyan, Ozkana, Ferda, Altas, Kemal
Format: Article
Language:English
Subjects:
acquired
Adolescent
Adult
Antibodies, Helminth - blood
Biological and medical sciences
Biopsy
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Hemagglutination Tests
Human protozoal diseases
Humans
Hyperplasia
Infectious diseases
Lymph nodes
Lymph Nodes - parasitology
Lymph Nodes - pathology
Lymphadenitis - parasitology
Main Articles
Male
Medical sciences
Middle Aged
Neck
Parasitic diseases
Predictive Value of Tests
Protozoal diseases
Toxoplasmosis
Toxoplasmosis - immunology
Toxoplasmosis - pathology
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Summary:Toxoplasmic lymphadenitis generally involves a solitary lymph node in the head and neck regions, without systemic symptoms. In order to determine the frequency of toxoplasmic lymphadenitis, we reviewed the histological sections of 731 consecutive patients with reactive lymph node hyperplasia. Amongst 731 patients, 112 had histological features supporting a diagnosis of toxoplasmic lymphadenitis (15.3 per cent). In 80 of these patients (71 per cent), either Indirect Haemaglutination test (IHA), in 37 cases, or the Enzyme-Linked Immunosorbent Assay (ELISA) for detecting toxoplasmic IgG or IgM antibodies, in 43 cases, were performed. In 76 out of 80 patients (95 per cent), histological features correlated well with serological studies. The IHA test was positive in 30 patients with a titre of 1/64 or higher. The IgG-ELISA test was positive in 11 whereas the IgM-ELISA test was positive in 28 patients. These results provide further evidence of the distinctive nature of the histological changes in toxoplasmic lymphadenitis, which should enable the clinician to make a confident diagnosis of acute acquired toxoplasmosis.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100133596