Risk Factors for Cervical Intraepithelial Neoplasia in Taiwan

A population-based case–control study was conducted in Taiwan between July 1991 and June 1994 to evaluate the significance between risk factors for cervical intraepithelial neoplasia (CIN) among Taiwanese women. Personal interviews were compiled with 288 histologically confirmed CIN who were matched...

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Bibliographic Details
Published in:Gynecologic oncology 1996-07, Vol.62 (1), p.10-18
Main Authors: Wang, Pair Dong, Lin, Ruey S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case-Control Studies
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - etiology
Contraception
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Logistic Models
Medical sciences
Odds Ratio
Papillomaviridae
Papillomavirus Infections
Risk Factors
Sexual Behavior
Taiwan - epidemiology
Tropical medicine
Tumor Virus Infections
Tumors
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - etiology
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Summary:A population-based case–control study was conducted in Taiwan between July 1991 and June 1994 to evaluate the significance between risk factors for cervical intraepithelial neoplasia (CIN) among Taiwanese women. Personal interviews were compiled with 288 histologically confirmed CIN who were matched by age to 576 randomly selected controls with normal cervical smears. Using logistic regression models to simultaneously evaluate the effects of multiple factors as predictors of CIN, we found that the strongest risk was associate with HPV infection (OR = 5.02). Other significant risks included husband's visiting prostitutes (OR = 2.56), four or more vaginal deliveries (OR = 2.01), two or more induced abortions (OR = 1.96), and multiple sex partners (OR = 1.87). A protective effect was also noted with the use of condoms (OR = 0.38). These data support the hypothesis that CIN is sexually transmitted in Taiwan's population and may have a viral etiology. Furthermore the results indicate the important role of the husband's visiting prostitutes and the nonuse of condoms as contributing factors in the high incidence rate for CIN in a population.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.1996.0183