Analysis of morbid events and risk factors for death after cardiac transplantation

Risk factors for death after cardiac transplantation performed at the University of Alabana at Birmingham from January 1981 to July 1985 included (by multivariate analysis) higher calculated preoperative pulmonary vascular resistance (early and constant phases), murphology of cardiomyopathy (versus...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 1988-05, Vol.11 (5), p.917-924
Main Authors: Kirklin, James K, Naftel, David C, McGlffin, David C, McVay, Reba F, Blackstone, Eugene H, Karp, Robert B
Format: Article
Language:English
Subjects:
Acute Disease
Azathioprine - therapeutic use
Bacterial Infections - etiology
Biological and medical sciences
Cardiomyopathies - surgery
Cyclosporins - therapeutic use
Death, Sudden
Diseases of the osteoarticular system
Follow-Up Studies
Graft Rejection
Heart Arrest - etiology
Heart Transplantation
Humans
Medical sciences
Osteoarthritis
Postoperative Complications - etiology
Reoperation
Risk Factors
Time Factors
Vascular Resistance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Risk factors for death after cardiac transplantation performed at the University of Alabana at Birmingham from January 1981 to July 1985 included (by multivariate analysis) higher calculated preoperative pulmonary vascular resistance (early and constant phases), murphology of cardiomyopathy (versus ischemic heart disease) (constant phase only) and black race (constant phase). overall actuarial survival was 71% at 1 year and 48% at 3 years (including azalhioprine and cyclosporine eras). The hazard function for death was highest immediately after operation and declined rapidly thereafter, merging with a constant phase of risk at about 3 months. The most favorable group for long-term survival was the group of white patients with ischemic heart disease and low pulmonary vascular resistance. When such patients had a pulmonary vascular resistance < 3 units m2, the 3 year survival rate exceeded 85%; The most common causes of death were acute rejection (24%) and infection (17%) The risk of infection remained highest during the first several months after any period of augmented immunosuppression.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(98)90045-6