PRECURSOR DIRECTED BIOSYNTHESIS OF PAULOMYCIN C BY METHIONINE

Paulomycin C is a member of a novel class of antibiotics, the paulomycins, which are produced by Streptomyces paulus UC 8560 and are active against a variety of pathogenic bacteria, including methicillin-resistant Staphylococcus aureus . Paulomycin C is an ester of propionic acid and has been detect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1988/02/25, Vol.41(2), pp.253-254
Main Authors: LABORDE, A. L., CIALDELLA, J. I., SHILLIDAY, F. B., MARSHALL, V. P.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Biotechnology
Chromatography, High Pressure Liquid
Cyclohexenes
Disaccharides
Fermentation - drug effects
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
methionine
Methionine - pharmacology
Microbiology
paulomycin C
Production of active biomolecules
Streptomyces - drug effects
Streptomyces - metabolism
Streptomyces paulus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Paulomycin C is a member of a novel class of antibiotics, the paulomycins, which are produced by Streptomyces paulus UC 8560 and are active against a variety of pathogenic bacteria, including methicillin-resistant Staphylococcus aureus . Paulomycin C is an ester of propionic acid and has been detected in fermentations of S. paulus in synthetic medium to which methionine has been added. The authors report the effect of various concentrations of methionine on paulomycin C production.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.253