IL-8 in pleural effusion

Interleukin-8 (IL-8) is a recently described potent chemotactic factor that may be involved in the pathogenesis of pleural effusions. To understand the actual mechanisms mediating the inflammatory response, changes in cellular components and IL-8 level in pleural fluid of different aetiologies were...

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Bibliographic Details
Published in:Respiratory medicine 1996-04, Vol.90 (4), p.215-221
Main Authors: Ceyhan, B.Bağci, Özgün, S., Çelikel, T., Yalçin, M., Koç, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Empyema, Pleural - immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-8 - analysis
Interleukin-8 - blood
Leukocyte Count
Male
Medical sciences
Middle Aged
Neutrophils - pathology
Pleural Effusion - immunology
Pleural Effusion - pathology
Pleural Effusion, Malignant - immunology
Pleural Effusion, Malignant - pathology
Pneumology
Respiratory system : syndromes and miscellaneous diseases
Tuberculosis, Pleural - immunology
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Summary:Interleukin-8 (IL-8) is a recently described potent chemotactic factor that may be involved in the pathogenesis of pleural effusions. To understand the actual mechanisms mediating the inflammatory response, changes in cellular components and IL-8 level in pleural fluid of different aetiologies were evaluated. Thirty-four patients (19 male, 15 female) with a mean age of 46 ± 22 years (range 16–92) were included in the study. Of these, 13 had tuberculous pleural effusion, seven had empyema/parapneumonic pleural effusion, and 14 had malignant pleural effusion (seven adenocarcinoma, three ovarian carcinoma, two lymphoma, one chronic myeloid leukaemia, and one small cell carcinoma) with positive cytology. Differential cell counts in the pleural fluid were obtained using cytocentrifuge preparations. The concentrations of IL-8 in pleural fluid were measured by the ELISA method. Interleukin-8 was detected in all 34 pleural fluid samples. The serum IL-8 level was analysed only in the empyema/parapneumonic pleural effusion group The mean IL-8 levels of tuberculous, empyema/parapneumonic, and malignant pleural effusions were 1420 ± 1049 pg ml −1, 4737 ± 2297 pg ml −1, and 1574 ± 1079 pg ml −1, respectively. The IL-8 levels in the empyema/parapneumonic group were significantly raised over malignant and tuberculous groups ( P
ISSN:0954-6111
1532-3064
DOI:10.1016/S0954-6111(96)90290-5