Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13

C1r and C1s are distinct, but structurally and functionally similar, serine protease zymogens responsible for the enzymatic activity of the first component of complement (C1). Recent comparisons indicate a significant degree of sequence similarity between C1r and C1s and support the hypothesis that...

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Bibliographic Details
Published in:Human genetics 1988-04, Vol.78 (4), p.363-368
Main Authors: NGUYEN VAN CONG, TOSI, M, GROSS, M. S, COHEN-HAGUENAUER, O, JEGOU-FOUBERT, C, DE TAND, M. F, MEO, T, FREZAL, J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 12
Classical genetics, quantitative genetics, hybrids
Complement Activating Enzymes - genetics
Complement C1 - genetics
Complement C1r
Complement C1s - genetics
Cricetinae
Cricetulus
DNA - genetics
Fundamental and applied biological sciences. Psychology
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Hybrid Cells - analysis
Mice
Nucleic Acid Hybridization
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Summary:C1r and C1s are distinct, but structurally and functionally similar, serine protease zymogens responsible for the enzymatic activity of the first component of complement (C1). Recent comparisons indicate a significant degree of sequence similarity between C1r and C1s and support the hypothesis that they are related by gene duplication. Complementary DNA probes for human C1r and C1s do not cross-hybridize even at mild stringency conditions and are therefore gene-specific. Using a panel of 25 human-rodent cell hybrids, we have independently assigned the C1r and the C1s genes to chromosome 12. In situ hybridization analyses were consistent with these assignments, showing in addition that both C1r and C1s are located on the short arm of the chromosome in the region p13. These data suggest that the homologous C1r and C1s genes have remained closely linked after duplication of a common ancestor. The C1r and C1s loci also provide useful polymorphic DNA markers for the short arm of chromosome 12.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00291737