The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family

• Published in: FEBS letters 1988-04, Vol.231 (1), p.164-171
• Main Authors: Wathelet, Marc G., Clauss, Isabelle M., Content, Jean, Huez, Georges A.
• Format: Article
• Language: English
• Subjects: Amino Acid Sequence; Analysis of the immune response. Humoral and cellular immunity; Base Sequence; Biological and medical sciences; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 13; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation; Genes; Humans; IFN, interferon; Immunobiology; Interferon Type I - physiology; Lymphokines, interleukins ( function, expression); Molecular Sequence Data; Molecular Weight; Needleman-Wunsch-Sellers algorithm; poly(rI)·poly(rC), polyriboinosinic-polyribocytidylic acid; Poly(rI)·poly(rC)-inducible gene; Regulatory factors and their cellular receptors; Sequence comparison; Virus-inducible gene
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(88)80724-5

The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene.