Development of retroviral vectors as safe, targeted gene delivery systems

The transfer of genes of potential therapeutic benefit is presently being attempted in the clinic to treat a number of genetic and virally induced diseases. Many of these protocols use retroviral vectors derived from murine leukemia retroviruses as gene delivery systems. Although these viral deliver...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 1996-04, Vol.74 (4), p.171-182
Main Authors: GÜNZBURG, W. H, SALMONS, B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Gene Transfer Techniques
Genetic engineering
Genetic technics
Genetic Therapy - methods
Genetic Vectors
Methods. Procedures. Technologies
Retroviridae - genetics
Vectors (cloning, transfer, expression). Insertion sequences and transposons
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Summary:The transfer of genes of potential therapeutic benefit is presently being attempted in the clinic to treat a number of genetic and virally induced diseases. Many of these protocols use retroviral vectors derived from murine leukemia retroviruses as gene delivery systems. Although these viral delivery systems are well suited for this purpose, a number of their characteristics, some of which are discussed here, are still troublesome. Future retroviral vectors will incorporate nonretroviral features and will be tailored to desired needs for specific uses. These vectors will be safer, more efficient, and targeted in their delivery. Further, expression of the therapeutic genes carried will be limited to the specific target cell type. Some of the recent advances that have been made towards this goal are reviewed here.
ISSN:0946-2716
1432-1440
DOI:10.1007/BF00204747