COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS (1994): I. SUSCEPTIBILITY DISTRIBUTION

• Published in: Japanese journal of antibiotics 1996/05/25, Vol.49(5), pp.465-493
• Main Authors: KUMAMOTO, YOSHIAKI, HIROSE, TAKAOKI, YOKOO, AKIFUMI, HIKICHI, YOSHINAO, SHIGETA, SHIRO, SHIRAIWA, YASUO, KAMEOKA, HIROSHI, YOSHIDA, HIROSHI, TAZAKI, HIROSHI, IRI, HISAMI, UCHIDA, HIROSHI, KOBAYASHI, YOSHIO, MATSUDA, SEIJI, FUJIME, MAKOTO, FUJITA, KAZUHIKO, KITAGAWA, RYUICHI, IGARI, JUN, OGURI, TOYOKO, KOSAKAI, NOZOMU, YAMAGUCHI, KEIZO, KASHITANI, FUSAKO, YONEZU, SEIBUN, YAMANAKA, YOSHITAKA, TAKAHA, MINATO, TSUJIMURA, AKIRA, TANAKA, MICHIO, KAKU, MITSUO, IORI, FUMIAKI
• Format: Article
• Language: Japanese
• Subjects: Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacteria - isolation & purification; Bacterial Infections - microbiology; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - isolation & purification; Gram-Positive Bacteria - drug effects; Gram-Positive Bacteria - isolation & purification; Humans; Japan; Microbial Sensitivity Tests; Urinary Tract Infections - microbiology
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.49.465

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 567 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1994 to May 1995. Of the above total bacterial isolates, Gram-positive bacteria accounted for 26.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 73.2% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC) and imipenem (IPM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 1μg/ml. Vancomycin (VCM) was also active with the MIC90 of 2μg/ml. Piperacillin (PIPC) and biapenem (BIPM) were also active with the MIC90s of 4μg/ml and 8μg/ml, respectively. The others were not so active with the MIC90s of 16μg/ml or above. 2. Staphylococcus aureus including MRSA VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml against both S. aureus and MRSA. Arbekacin (ABK) was also active with the MIC90 of 2μg/ml. The others except minocycline (MINO) were not so active with the MIC90s of 64μg/ml or above. 3. Staphylococcus epidermidis MINO showed the strongest activity against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 0.25μg/ml. ABK was also active with the MIC90 of 1μg/ml. Cephems were active with the MIC90s of 2-16μg/ml, but penicillins and quinolones were not so active with the MIC90s of 64-128μg/ml. 4. Citrobacter freundii Gentamicin (GM) showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml. IPM was also active with the MIC90 of 2μg/ml. Cefpirome (CPR) and cefozopran (CZOP) were also active with the MIC90s of 4μg/ml and 8μg/ml. The others were not so active with the MIC90s of 32μg/ml or above. 5. Enterobacter cloacae IPM showed the highest activities against E. cloacae. Its MIC90 was 0.5μg/ml. GM and amikacin (AMK), ciprofloxacin (CPFX) and tosufloxacin (TFLX) were also active with the MIC90s of 4μg/ml. Penicillins and cephems except latamoxef (LMOX), cefmenoxime (CMX), CPR and CZOP showed lower activities with the MIC90s of 256μg/ml or above. 6. Escherichia coli Most of antimicrobial agents were active against E. coli. CPR, CZOP, IPM, carumonam (CRMN), CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them were