A Member of the MAP Kinase Phosphatase Gene Family in Mouse Containing a Complex Trinucleotide Repeat in the Coding Region

We have identified a novel mouse gene encoding a protein that shows high homology to the dual-specificity tyrosine/threonine phosphatase family of proteins. The gene encodes a 5 kb transcript which is expressed predominantly in brain and lung and contains a translated complex trinucleotide repeat wi...

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Bibliographic Details
Published in:Human molecular genetics 1996-05, Vol.5 (5), p.675-684
Main Authors: Theodosiou, A. M., Rodrigues, N. R., Nesbit, M. A., Ambrose, H. J., Paterson, H., McLellan-Arnold, E., Boyd, Y., Leversha, M. A., Owen, N., Blake, D. J., Ashworth, A., Davies, K. E.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Blotting, Northern
Brain Chemistry
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
DNA, Complementary - chemistry
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
In Situ Hybridization, Fluorescence
Mice
Microinjections
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Open Reading Frames
Protein Biosynthesis
Protein Tyrosine Phosphatases - genetics
RNA, Messenger - metabolism
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Signal Transduction - genetics
Subcellular Fractions - chemistry
Transcription, Genetic
Transfection
Trinucleotide Repeats
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Description
Summary:We have identified a novel mouse gene encoding a protein that shows high homology to the dual-specificity tyrosine/threonine phosphatase family of proteins. The gene encodes a 5 kb transcript which is expressed predominantly in brain and lung and contains a translated complex trinucleotide repeat within the coding region. Using interspecific mouse backcross analysis, the gene has been localised to distal mouse chromosome 7. In human, homologous sequences are located in the syntenic region on distal chromosome 11p as well as to chromosome 10q11.2 and 10q22. The presence of a CG-rich trinucleotide repeat in the coding region provides a target for mutation which might result in loss of function or altered properties of this phos-phatase.
ISSN:0964-6906
1460-2083
1460-2083
DOI:10.1093/hmg/5.5.675