Does growth-hormone supplementation affect adult height in Turner's syndrome?

By comparison with historical controls, the effect of treatment with growth hormone on adult height in Turner's syndrome was initially reported as uniformly and strongly positive. Because randomised controlled trials are not near completion, we report our experiences in an open study. We examin...

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Bibliographic Details
Published in:The Lancet (British edition) 1996-07, Vol.348 (9019), p.25-27
Main Authors: Taback, Shayne P, Collu, Robert, Deal, Cheri L, Guyda, Harvey J, Salisbury, Sonia, Dean, Heather J, Vliet, Guy Van
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Height - drug effects
Child
Child, Preschool
Female
Girls
Growth Hormone - pharmacology
Growth Hormone - therapeutic use
Height
Hormones
Hormones. Endocrine system
Humans
Medical disorders
Medical sciences
Pharmacology. Drug treatments
Recombinant Proteins - pharmacology
Recombinant Proteins - therapeutic use
Turner Syndrome - drug therapy
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Summary:By comparison with historical controls, the effect of treatment with growth hormone on adult height in Turner's syndrome was initially reported as uniformly and strongly positive. Because randomised controlled trials are not near completion, we report our experiences in an open study. We examined adult height, projected and attained, in 31 patients (17 treated with subcutaneous recombinant human growth hormone, up to 15 mg a week, outside of a controlled trial and 14 untreated contemporaries). Contingency table analysis of attained versus projected height showed significantly higher values in treated patients although only 4 of 17 had final heights of 5 cm or more over projection. Patients' and treatment variables (height, bone-age delay, oestrogen replacement) that interfere with adult height projection confounded the analysis of adult height data. Girls with Turner's syndrome should be counselled cautiously about the expectation of a strongly positive effect of treatment on adult height. Completion of the randomised controlled trials to adult height is needed to establish the effect of growth-hormone supplementation on adult height in Turner's syndrome and the psychological effect of treatment.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(96)01267-6