Lineage-specific CaN19 expression in human skin: lack of expression in normal melanocytes

Although expression of CaN19 is reduced in cell lines derived from tumors of diverse origin, its expression in their normal counterparts has not been studied in detail. We find that CaN19 mRNA is expressed at very low to undetectable levels in normal melanocytes as well as malignant melanoma cell li...

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Bibliographic Details
Published in:Journal of dermatological science 1996-04, Vol.12 (1), p.69-72
Main Authors: Andersen, Lone B., Xia, Longqing, Stoll, Stefan, Zhao, Xinping, Elder, James T.
Format: Article
Language:English
Subjects:
Cells, Cultured
Fibroblasts - metabolism
Gene Expression
Genes, Tumor Suppressor
Humans
Keratinocytes - metabolism
Melanocytes
Melanocytes - metabolism
Melanoma
Melanoma - genetics
Melanoma - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
S-100 proteins
Skin - cytology
Skin - metabolism
Tumor Cells, Cultured
Tumor suppressor genes
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Summary:Although expression of CaN19 is reduced in cell lines derived from tumors of diverse origin, its expression in their normal counterparts has not been studied in detail. We find that CaN19 mRNA is expressed at very low to undetectable levels in normal melanocytes as well as malignant melanoma cell lines, confirming that CaN19 expression in normal cells is lineage-dependent.
ISSN:0923-1811
1873-569X
DOI:10.1016/0923-1811(95)00497-1