Effect of 6-Iodoamiloride in Various Models of Experimental Hypertension

6-Iodoamiloride, an analogue of the sodium channel blocker amiloride, Is a vasodilator-depressor, diuretic-natriuretic, and antikaliuretic agent. In these experiments we intravenously infused 6-iodoamiloride (0.38 mg/100 g body weight) over a 10- to 11-minute period into rats with reduced renal mass...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1988-05, Vol.11 (5), p.445-451
Main Authors: PAMNANI, MOTILAL B, RINAUDO, MARIO S, HADDY, FRANCIS J, CRAGOE, EDWARD J
Format: Article
Language:English
Subjects:
Amiloride - administration & dosage
Amiloride - analogs & derivatives
Amiloride - pharmacology
Animals
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Diuresis - drug effects
Hypertension - physiopathology
Hypertension, Renovascular - physiopathology
Infusions, Intravenous
Male
Medical sciences
Natriuresis - drug effects
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Rats, Inbred WKY
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Summary:6-Iodoamiloride, an analogue of the sodium channel blocker amiloride, Is a vasodilator-depressor, diuretic-natriuretic, and antikaliuretic agent. In these experiments we intravenously infused 6-iodoamiloride (0.38 mg/100 g body weight) over a 10- to 11-minute period into rats with reduced renal mass-saline hypertension or one-kidney, one clip hypertension. The infusion produced a prompt but transient fall in blood pressure. These findings are in contrast to those in spontaneously hypertensive rats (SHR), in which the same infusion of 6-iodoamiloride produced a prompt, pronounced, and sustained fall in blood pressure. Studies from a number of laboratories suggest that vascular smooth muscle cells from the SHR have increased permeability to sodium whereas vascular smooth muscle cells from the other two models do not. Thus, 6-iodoamiloride may have potential both as a diagnostic probe and a therapeutic agent for hypertension characterized by increased vascular smooth muscle cell permeability to sodium.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.11.5.445